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Assessing the clinical and cost-effectiveness of endovascular vs open revascularisation in severe occlusive aorto-iliac disease (EVOCC trial): study protocol for a randomised controlled trial

Por: Saratzis · A. · Davies · A. · Diamantopoulos · A. · Davies · R. S. M. · Epstein · D. · Jepson · M. · Perez · D. · Apergi · D. · Harris · K. J. · Zayed · H. · Brookes · C. · Barber · S. · Suazo Di Paola · A. · Ingram · L. · Richardson · C. · Patel · A.
Introduction

Severe aorto-iliac steno-occlusive atherosclerotic disease is a major cause of morbidity and amputation in patients with peripheral arterial disease. While both open surgical and endovascular revascularisation are standard treatments in this patient group, there is no high-quality randomised evidence to determine which approach offers superior clinical and cost-effectiveness, leading to uncertainty and poor outcomes after intervention.

Methods and analysis

The EVOCC trial is a national, multicentre, parallel-group, superiority randomised controlled trial comparing open surgery to endovascular revascularisation in patients with symptomatic severe aorto-iliac occlusive disease. A total of 628 participants across 30 NHS sites in the UK will be randomised 1:1 to receive either open surgery or endovascular (minimally invasive) intervention. The primary outcome is amputation-free survival, defined as time to first event (major lower limb amputation or death). Secondary outcomes include mortality, cardiovascular events, hospital readmissions, re-interventions and quality-of-life measures. An internal pilot phase (10 sites, 6-month duration) will assess recruitment feasibility. A QuinteT Recruitment Intervention is integrated into the trial to optimise recruitment.

Ethics and dissemination

The trial has received ethical approval from a UK Research Ethics Committee (REC reference: 23/SW/0065; trial registration reference: ISRCTN14591444). Informed consent will be obtained from all participants.

The EVOCC trial is the first RCT assessing the clinical and cost-effectiveness of open vs endovascular revascularisation for severe aorto-iliac disease worldwide. The results will provide robust evidence to inform clinical practice and healthcare policies globally. Results will be disseminated via patient groups, online lay summaries, a trial website, social media, presentations in conferences, a formal scientific publication in a medical journal and direct communications with policymakers across borders.

Trial registration number

ISRCTN14591444.

Closed‐Incision Negative Pressure Therapy: Scoping Review and Multidisciplinary Consensus Recommendations of the Spanish Observatory of Infection in Surgery

ABSTRACT

Surgical site infections (SSI) and surgical site complications (SSC) significantly impact surgery outcomes, increasing hospital stays and mortality rates, and negatively affecting patients' quality of life. Closed-incision negative pressure therapy (ciNPT) emerged as a prophylactic strategy to reduce these complications. However, its applicability across different surgical procedures remains unclear. A scoping review was conducted to synthesise the available evidence on the use of ciNPT in different surgical contexts. A multidisciplinary panel of experts from different surgical specialties was assembled to identify patient risk factors for SSCs specific to each modality. Surgical procedures were categorised based on anticipated SSC rates and the impact of SSI. A decision diagram was finally developed, providing tailored recommendations for ciNPT use according to individual surgical circumstances. The findings of the review indicate that ciNPT effectively reduces SSI and SSC in most surgical procedures. Key patient-related factors influencing outcomes, such as age, obesity, and malnutrition, were outlined. Additionally, a specialty-based list of surgical procedures was compiled, specifying whether ciNPT is recommended, not recommended, or conditionally recommended based on specific criteria. This study underscores the benefits of ciNPT and provides a comprehensive guide to its application across several surgical specialties, aiming to optimise patient management and inform clinical practise.

Satisfacción materna con la atención recibida durante el parto y puerperio y su relación con factores asociados

Objetivo. Evaluar el grado de satisfacción con los cuidados brindados durante el parto y el posparto en el Hospital Álvaro Cunqueiro (HAC) y explorar su posible relación con variables sociodemográficas y obstétricas. Metodología. Se realizó un estudio observacional descriptivo transversal. La población incluyó mujeres con partos entre enero y octubre de 2024 en el HAC. El muestreo fue no probabilístico y de tipo consecutivo. Para la recolección de datos, se utilizó un cuestionario ad hoc que recopiló información sobre variables sociodemográficas y obstétricas, complementado con el instrumento “Care in Obstetrics: Measure for Testing Satisfaction” (COMFORTS) en su versión validada en español. Resultados. La muestra estuvo compuesta por 319 mujeres. La mediana de satisfacción global obtenida con el cuestionario COMFORTS fue de 171 (RIC: 155–186), lo que indica un alto nivel de satisfacción general. Sin embargo, las áreas de cuidados en el posparto [Me: 46 (RIC: 40–53)] y al recién nacido [Me: 40 (RIC: 30–46)] fueron identificadas como susceptibles de mejora. Se encontró una relación estadísticamente significativa entre la paridad y la percepción de la calidad de los cuidados neonatales, así como entre el modo de finalización del parto y el grado de satisfacción materna con la experiencia del parto. Discusión. Aunque la satisfacción general con los cuidados obstétricos en el HAC es alta, existen áreas de mejora en el posparto y en la atención al recién nacido. Además, variables como la paridad y el modo de finalización del parto influyen en la percepción materna de los cuidados.

ABSTRACT

Objective. To assess the degree of satisfaction with the care provided during labor and postpartum at the Hospital Álvaro Cunqueiro (HAC) and to explore its possible relationship with sociodemographic and obstetric variables. Methodolgy. A cross-sectional descriptive observational study was conducted. The population included women with deliveries between January and October 2024 at the HAC. Sampling was non-probabilistic and consecutive. For data collection, an ad hocquestionnaire was used to obtain information on sociodemographic and obstetric variables, complemented with the instrument Care in Obstetrics: Measure for Testing Satisfaction (COMFORTS) in its validated Spanish version. Results.The sample consisted of 319 women. The median overall satisfaction with the COMFORTS questionnaire was 171 (IQR: 155–186), indicating a high level of overall satisfaction. However, the areas of postpartum [Me: 46 (IQR: 40–53)] and newborn care [Me: 40 (IQR: 30–46)] were identified as areas for improvement. A statistically significant relationship was found between parity and perceived quality of neonatal care, as well as between the mode of delivery and maternal satisfaction with the birth experience. Discussion: Although overall satisfaction with obstetric care at the HAC is high, there are areas for improvement in postpartum and newborn care. In addition, variables such as parity and mode of delivery influence maternal perceptions of care.

Efficacy and safety of dexamethasone compared to placebo in patients with severe influenza infection. (FLUDEX study): a study protocol for a randomised controlled trial in Spain

Por: Ramos-RIncon · J.-M. · Cebollada · J. · Giner · L. · Paz Ventero · M. · Moreno-Perez · O. · Otero-Rodriguez · S. · Sanchez-Paya · J. · Rodriguez · J. C. · Merino · E.
Introduction

The combination with corticosteroids as immunomodulators has been the subject of debate in different infectious syndromes. The main objective of this study is to evaluate the efficacy (the percentage of patients hospitalised with influenza with a status of 3 or higher according to the Hospital Recovery Scale (HRS) on day 7 after the start of treatment) and safety of dexamethasone.

Methods and analysis

Investigator-initiated multicentre, blinded, randomised placebo-controlled trial with two parallel treatment arms. The study population will consist of adult patients (over 18 years of age) hospitalised with severe influenza. One arm will receive one capsule of 6 mg of dexamethasone for 7 days, and the other arm will receive one capsule of placebo for 7 days of antibiotic treatment for 7 days or longer. Both groups will receive oseltamivir (75 mg/12 hours orally) for 5 days, extendable to 10 days depending on the investigator decision. Randomisation will occur in equal proportion (1:1). Patients with bronchial hyper-responsiveness that requires systemic corticosteroids for more than 24 hours, preinclusion treatment with corticosteroids for more than 24 hours at a dose equal to or higher than 1 mg/kg methylprednisolone (0.2 mg/kg dexamethasone or 1.25 mg/kg prednisone), inability to administer oral oseltamivir, patients with severe comorbidity with a life expectancy of

Ethics and dissemination

The study is approved by the Institutional Review Board of Alicante Health Department—Dr. Balmis General University Hospital (LOC-100061146). The results of the main trial and each of the secondary endpoints will be submitted for publication in a peer-reviewed journal

Trial registration number

NCT06528444.

Evaluating the health and well-being effects of increasing biodiversity within multiple small parks in Edinburgh, UK: a protocol for a mixed-methods, longitudinal, pre-post natural experiment

Por: Malden · S. · McDougall · C. W. · Ward Thompson · C. · Wendelboe-Nelson · C. · Ross-Perez · A. · Clemens · T. · Mason · S. · Villegas-Diaz · R. · Hoadley · A. · Hunter · A. · Jepson · R. · Williams · A. J.
Introduction

Recent legislation in the UK regarding requirements for new developments to increase biodiversity may have significant implications for the environment and population health. Despite this, relatively little is known regarding the health and social benefits of increasing biodiversity in densely populated urban areas.

Methods and analysis

This protocol outlines plans for a mixed-method, longitudinal, natural experiment study which will evaluate the planned, biodiversity-focused redevelopment of six small urban parks in Edinburgh, Scotland (UK). Using systematic observation (at baseline, 1 month post-intervention and 1 year post-baseline) and a longitudinal household survey (at baseline and 1 year post-baseline), the primary outcomes of personal well-being, and secondary outcomes of nature connectedness and park usage behaviours, will be assessed, respectively. Consent for data linkage of respondent’s health records will also be sought. Process evaluation will employ semi-structured, qualitative interviews with stakeholders and walk-along interviews with local residents in order to understand implementation processes. Space-related well-being will also be assessed using citizen science approaches.

Ethics and dissemination

This study was approved by the University of Edinburgh’s School of Health in Social Sciences ethics committee. This study will provide further evidence for policymakers, the public and researchers of the health and social well-being effects of urban biodiversity interventions. Study findings will be disseminated via public forums such as community workshops and through publication in peer-reviewed journals and presentation at scientific conferences.

Comparison of treatment efficacy between topical insulin and autologous serum in persistent epithelial defects: a randomised controlled trial protocol in Spain

Por: Arriola-Villalobos · P. · Burgos-Blasco · B. · Ascaso-del-Rio · A. · Medina-Ramirez · L. · Rivas · A. B. · Perez-Macias · N. · Diaz-Valle · D. · Portoles-Perez · A.
Background

Persistent epithelial defect (PED) management can be challenging. First line of treatment includes lubrication, bandage contact lenses and punctal plugs. The second line of treatment includes autologous serum (AS). Topical insulin has been shown to be safe for topical use and improve corneal epithelial healing. Therefore, a controlled clinical trial (control group with current standard treatment, ie, AS) multicentre, randomised and with a blind third observer will be conducted to evaluate the efficacy and safety of the use of insulin eye-drops in the treatment of PED.

Methods and analysis

A preselection of patients with epithelial defect after 1 week of treatment will be made and blood tests will be obtained in order to dispense AS if necessary. After 2 weeks of standard treatment, if the PED persists and the patient meets criteria, patients will be enrolled after signing an informed consent form. Patients will be randomly allocated to receive either insulin (1 UI/mL, 4 times a day) or AS (20%, 5–6 times a day) eye-drops for 3 months. 234 patients will be included, 117 in each treatment group. The main variable (PED size) will be obtained from slit-lamp photographs, an objective and easily quantifiable variable which will be evaluated by a blinded investigator (third observer). Patients will be examined every 3–5 days until week 4 of study treatment and once a week until 6 weeks, to continue with a visit every 2 weeks until reaching 3 months of follow-up. Primary endpoints are: complete epithelialisation, epithelialisation rate (initial defect area/days until epithelialisation) and time until complete closure.

Ethics and dissemination

Ethical approval has been obtained from Hospital Clinico San Carlos in Madrid and Agencia Española del Medicamento y Productos Sanitarios (AEMPS). The findings will be disseminated in peer-reviewed publications and presentations at meetings.

Trial registration number

EudraCT 2022-003589-19.

Development of a core outcome set for the trials of complementary therapies in people with multiple sclerosis: international survey and consensus meetings

Por: Lopez-Alcalde · J. · Tietjen · A. K. · Yan · Y. · Canella · C. · Barth · J. · Steinemann · N. · Hägele-Link · S. · Bolt · S. · Baum · C. · Rettenmund · G. · von Wyl · V. · Nonino · F. · Wieland · L. S. · Wang · X. · Schmick · A. · Pagnini · F. · Kesselring · J. · Khazaei · H. · Perez-Ner
Objectives

This study aimed to develop a core outcome set (COS) for trials evaluating the effects of complementary therapies in people with multiple sclerosis (pwMS). We sought to identify the outcomes most relevant to pwMS, their relatives and friends, healthcare professionals and researchers and to propose these for inclusion in future trials.

Design

A participatory international research project using a mixed-method approach with qualitative and quantitative methods. The study included a scoping review and a national survey in Switzerland to identify candidate outcomes, followed by an international COS survey to rate the importance of these outcomes. The final phases involved two consensus meetings to refine and finalise the COS.

Setting

Data were sourced from the published literature and input from international stakeholders.

Participants

pwMS and other relevant stakeholders, including their relatives and friends, healthcare professionals and researchers.

Results

A total of 770 individuals participated in the international COS survey of 39 candidate outcomes (662 pwMS, 27 relatives/friends, 58 healthcare professionals and 23 researchers). According to the survey results, 13 outcomes were added to the COS, 5 were excluded and 21 were classified as ‘no consensus’. 13 individuals (six pwMS, one pwMS’s friend, three healthcare professionals and three researchers) attended the first consensus meeting. Following the voting on the outcomes without consensus, seven outcomes were added to the COS, four were excluded and 10 outcomes were still classified as ‘no consensus’. The six members of the stakeholders advisory board (one pwMS, four healthcare professionals and two researchers) attended the second consensus meeting to define the final COS. Nine additional outcomes were included in the COS. Sexual problems, an outcome previously excluded, were also added. In total, 30 outcomes were included in the final COS.

Conclusion

We have developed the first COS for future trials of complementary therapies for pwMS. The use of this COS will promote that future research in complementary therapies is relevant for pwMS and other stakeholders involved in MS care. Future COS research should integrate diverse geographical regions, where perspectives and access to complementary therapies may vary.

Study registration number

https://osf.io/ys7xt/.

La vida después de un cáncer, experiencias de un grupo de sobrevivientes

Introducción: El cáncer es una enfermedad compleja y desafiante que afecta no solo la salud física, sino también las dimensiones emocionales, sociales y espirituales de los individuos. Objetivo: Describir las experiencias de un grupo de personas sobrevivientes al cáncer. Método: Se llevó a cabo un estudio cualitativo de tipo etnográfico. La saturación teórica se alcanzó con la participación de 15 personas sobrevivientes de cáncer seleccionadas mediante muestreo en bola de nieve. La recolección de datos se realizó mediante entrevistas semiestructuradas, previo consentimiento informado de los participantes, utilizando la guía propuesta por Leininger para el análisis de datos cualitativos. Resultados: La experiencia de los participantes al haber superado el cáncer se describió en cuatro categorías: el cáncer como sinónimo de muerte, el apoyo familiar, la resiliencia como recurso psicológico crucial y la importancia de la fe en Dios como un bálsamo de vida. Conclusiones: La experiencia de recuperación ante un cáncer comienza con incertidumbre y miedo, asociando inicialmente el diagnóstico con la muerte; pero, con el tiempo, los sobrevivientes logran enfrentar la enfermedad desarrollando una actitud resiliente.

Examining the Association Between Perceived Quality of Care and Experienced Coercion Among Patients in Acute Mental Health Units in Spain: A National Cross‐Sectional Study

ABSTRACT

Aim

To examine the association between perceived quality of care and the level of coercion experienced by individuals hospitalised in acute mental health units.

Design

National cross-sectional study.

Methods

Data were collected from 255 patients admitted to 12 acute mental health units across Spain. Standardised instruments assessed perceived quality of care and levels of coercion, humiliation and fear at discharge. Multiple linear regression analyses were used to explore associations between care quality dimensions and patients' experiences.

Results

Perceived quality of care was significantly associated with lower levels of perceived coercion and humiliation. All dimensions of care quality showed inverse associations, with the “secluded” dimension showing the strongest association. The association between care quality and perceived fear was less consistent. These findings are particularly relevant for mental health nurses, who play a central role in delivering relational care and ensuring patients' emotional safety.

Conclusion

Higher perceived quality of care is associated with lower levels of coercion, humiliation, and fear during hospitalisation in acute mental health settings.

Implications for the Profession and/or Patient Care

For mental health nursing, these results underscore the critical role of nurses in creating therapeutic environments that reduce coercive experiences. By fostering trust, promoting patient autonomy, and ensuring emotional and physical safety, nurses can significantly influence the quality of care and patient outcomes.

Impact

The study addresses the lack of evidence on how perceived quality of care influences experiences of coercion in acute mental health settings. Better perceived care quality is linked to reduced feelings of coercion, humiliation and fear. The research has direct implications for mental health nurses, clinical educators and healthcare managers aiming to improve patient experiences and reduce coercive practices in psychiatric care.

Reporting Method

STROBE reporting guideline.

Patient or Public Contribution

No patient or public contribution.

Emotion regulation intervention to promote well-being through a serious game (emoWELL): a study protocol for a randomised controlled trial in Spanish emerging adults

Introduction

Emerging adulthood is a new life stage characterised by identity exploration, instability, self-focus, a feeling of ‘being in-between’ and the perception of a range of possibilities. Emerging adults may experience difficulties in their well-being during this complex stage. Adaptive emotion regulation can improve levels of well-being. Previous studies have shown that new technologies can enhance social-emotional competencies in this population. The purpose of the study is to design and implement a serious game, emoWELL, which improves knowledge and the use of adaptive skills of emotion regulation to improve well-being during emerging adulthood.

Methods and analysis

The participants will be 385 emerging adults aged 18–29 years. They will be randomly assigned to either the control or experimental group. The experimental group will complete the emoWELL serious game. The game takes place on a train ride with several stops where the player will learn about emotion regulation. To assess the effectiveness of emoWELL, psychological assessment instruments validated in the Spanish population will be used. The primary expected outcomes include characteristics of emerging adulthood, emotion regulation (emotion dysregulation, emotion regulation strategies and cognitive reappraisal and expressive suppression) and psychological well-being. The secondary expected outcomes are self-esteem, psychological distress, loneliness and optimism. The assessment will occur at two different time points: pretest (T1) and post-test (T2) to observe improvements in the variables of interest.

Ethics and dissemination

The study has been approved by the Ethics Committee of the Universitat de València (2013883) and will follow the standards of the Declaration of Helsinki for data collection. The findings will be shared with the scientific community. The intellectual property registration number is as follows: UV-SW-202460R.

Trial registration number

NCT06049407.

Strengthening universities response to sexual harassment with an equity approach: the UNI4EQUITY mixed-methods study protocol

Por: Vives-Cases · C. · Berbegal-Bernabeu · M. · Perez-Martinez · V. · Neves · S. · Munoz-Haba · A. · Van de Velde · S. · Jaskulska · S. · Porru · S. · Carta · A. · De Cuyper · A. · Carrasco · J. M. · Manchenko · M. · Jankowiak · B. · Wallner · M. · Stifter · V.
Introduction

Preventing online and offline sexual harassment (SH) is a public health priority, due to its worldwide magnitude and short- and long-term consequences to the victims and survivors. Universities are environments that may facilitate different forms of conflicts, including SH, but they also play a key role in preventing and addressing them. This paper describes ‘Uni4Equity’, a European project funded by the CERV-2022-DAPHNE Programme of the European Union (Ref. 101094121-Uni4Equity) aimed to reinforce universities’ readiness to identify, map and respond to online and offline SH at workplace and other relevant settings (classrooms, digital space), with an explicit (but not exclusive) focus on minority social groups. More specifically, the project will address the research needs of conducting multidimensional diagnosis of SH at universities (scale and determinants) as a basis for preventive actions; assessing the effectiveness of preventive interventions such as social media campaigns and training workshops; creating a university culture that actively rejects SH; improving access to existing support services; and contributing to the acknowledgement of universities as an asset in preventing this issue.

Methods and analyses

The project follows an exploratory sequential design for the period 2023–2026. In phase 1, a mixed-method initial assessment based on online surveys, semistructured interviews and desk reviews is planned in six targeted universities: University of Alicante, Adam Mickiewicz University (AMU), University of Maia, University of Applied Sciences Burgenland (UASB), University of Antwerp (UAntwerp), University of Verona. Phase 2 integrates long-term and large-scale interventions at different levels of prevention (primary, secondary and tertiary) and implementation (interpersonal, institutional and social). These interventions combine online and offline training programmes addressed to students and staff, arrangements with internal and external support services and improvements in access to information and resources, including SH protocols and regulations. Phase 3 consists of qualitative and quantitative evaluations of the different Uni4Equity interventions and a final evaluation of the global impact of the project.

Ethics and dissemination

Ethical approval was obtained by the different universities research ethics committees (Universidad de Alicante, vice-rectorate for research: Ref. no. UA-2023-03-27; Università di Verona, Comitato di Approvazione per la Ricerca sulla Persona: Ref. no. UNIVR-24/2023; UAntwerp, Ethics Committee for the Social Sciences and Humanities: Ref. no. EX_SHW_2023_38_1; AMU, Ethics Committee for Research Involving Human Participants, Ref. no. UAM_19/2022/2023; UASB, Ethics Committee: Ref. no. UASB _28/08/2023; Universidade da Maia, Conselho de Ética e Deontologia: Ref. no. UMAIA_ 151/2023).

The research team will disseminate findings through peer-reviewed journal articles, presentations in scientific national and international events, policy briefs, infographics, videos and short reports.

Let's Talk About the Elephant in the Room: A Psychological Safety Climate Intervention Among Nursing Teams—A Qualitative Evaluation

ABSTRACT

Aim

To explore how a staff and managers experienced a multi-component and multi-level intervention to influence the psychological safety climate within nursing teams.

Design

Qualitative, to explore the experiences of registered nurses, licensed practical nurses, and managers in a Swedish hospital.

Methods

Four focus group discussions were conducted in March 2023 with staff and managers (n = 20). A deductive thematic analysis was conducted, guided by a theoretical model of psychological safety, to examine work climate perceptions and antecedent conditions. An inductive approach was used to explore how participants experienced the intervention.

Results

Participants experienced a shift from a blame-oriented to a more psychologically safe work climate. These developments were enabled by enhanced self-awareness, more supportive interpersonal dynamics, and leaders adopting a more accessible and vulnerable role. The intervention created a safe space to reflect on team dynamics.

Conclusion

Sustained efforts that integrate self-awareness, interpersonal dynamics, and managerial support are important to intentionally develop psychological safety. The creation of safe spaces can serve as a first step to confront unaddressed group beliefs.

Implications for the Profession and/or Patient Care

Interventions aimed at improving psychology safety can have positive effects if they focus on developing individual trust and vulnerability, targeting group dynamics, and including leaders.

Impact

Problem addressed: Inadequate psychological safety among nursing teams, hindering effective collaboration. Main findings: By changing work conditions, the intervention led to improved perceived psychological safety. Research impact: Creating conditions for psychological safety can improve how teams function.

Reporting Method

COREQ-checklist.

Patient or Public Contribution

No PPI patient or public contribution.

Mortality Risk Following Delirium in Older Inpatients: A Systematic Review and Meta‐Analysis

ABSTRACT

Background

The onset of delirium in older inpatients is associated with worse outcomes, including longer length of hospital stay, loss of functionality, loss of cognitive function, sleep disorders, increased polypharmacy, higher rates of adverse effects, and mortality. Previous studies have analyzed mortality after delirium, but without discriminating between settings, time, or critical conditions.

Aims

To assess the pooled incidence of delirium and risk of mortality at different times after hospital admission in older people and its association with mortality and length of stay in hospitalized people aged 65 years or older.

Methods

This systematic review and meta-analysis included studies analyzing the incidence of delirium and mortality. MEDLINE, Scopus, and the Web of Science were searched from inception to December 2023. PRISMA guidelines were followed. Inclusion criteria were original peer-reviewed studies in medical hospital areas using validated screening or diagnostic methods and quantifying mortality at admission or after excluding surgical patients. Exclusion criteria were studies that included only participants with a single condition at baseline, such as cancer, pneumonia, or frailty, or who were admitted to a specific unit such as the intensive care unit, as well as studies that assessed delirium in surgical areas. Study quality was assessed with Joanna Briggs Institute Critical Appraisal tools. The statistical analysis was performed in RevMan v5.4.0 (Cochrane Collaboration, Oxford, UK), using a random-effects model to calculate incidence, mortality, and length of hospital stay along with their 95% confidence intervals (CIs). The PROSPERO registration number for the review was CRD42023491604.

Results

In the 32 included studies, the pooled cumulative incidence of delirium was 28.79% (95% confidence interval [CI] 24.06%, 33.51%). The mortality risk was higher in patients who had delirium during admission (odds ratio [OR] 5.23, 95% CI [3.45, 7.93]). This varied by time point: 1 month, OR 3.80 (95% CI 2.40, 6.00); 6 months, OR 3.48 (95% CI [2.01, 6.01]); 12 months, OR 2.73 (95% CI [2.07, 3.60]); 2 years, OR 2.09 (95% CI [1.57, 2.78]); and 5 years, OR 3.34 (95% CI [2.40, 4.64]). In the pooled analysis, mean length of hospital stay was 2.26 days (95% CI [0.54, 3.99]) longer in patients with delirium.

Linking Evidence to Action

This study shows the markedly increased risk of mortality in older people with delirium during hospital admission and over the first month, in addition to an increased length of stay. The onset of delirium leads to increased use of healthcare resources. These data help to quantify the impact that delirium has on the health of older people, with implications for health system management. The evidence highlights the need to implement preventive pharmacological treatment or multicomponent strategies that minimize the onset of delirium in the older population.

Trial Registration

The PROSPERO registration number for the review was: CRD42023491604, available at: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=491604

Factores de riesgo para la sobrecarga en cuidadores informales de personas mayores con demencia: una revisión rápida de las últimas evidencias

Introducción. El número de personas mayores está incrementando y esto lleva consigo un aumento de enfermedades relacionadas con la edad avanzada como la demencia. Se caracteriza por la pérdida de memoria u otras funciones mentales, que incapacita a los pacientes y precisan cuidados de otras personas, los cuidadores informales. El objetivo de esta revisión fue analizar los factores de riesgo que contribuyen a la sobrecarga en los cuidadores informales de personas mayores con demencia. Metodología. Se realizó una revisión rápida con metodología sistemática, en MEDLINE (PubMed), creando una estrategia de búsqueda (términos MeSH, palabras clave y los operadores booleanos). Resultados. Un total de 16 artículos fueron incluidos con diferentes metodologías. De todos ellos, se obtuvieron datos acerca del grado de demencia del anciano, el perfil y la carga del cuidador mediante la escala Zarit Burden Interview y factores que afectan a padecer mayor sobrecarga. Se comprobó que la mayoría de los cuidadores son mujeres de mediana edad y que conviven con el paciente sin importar el lugar de procedencia. Se expresa mayor sobrecarga sobre los cuidadores de pacientes con demencia que con aquellos pacientes sin ella. Discusión. Los cuidadores con mayor estrés y ansiedad, y cuyo grado de conocimientos acerca de la enfermedad es inferior a la media tienen una peor puntuación en la escala Zarit Burden Interview. Se debe prestar atención a los factores de riesgo para evitar situaciones de sobrecarga, siendo necesario el apoyo social, económico, emocional y familiar.

ABSTRACT

Introduction. The number of elderly people is increasing, and this brings with it an increase in age-related diseases such as dementia. It is characterized by the loss of memory or other mental functions, which incapacitates patients and requires care from other people, the informal caregivers. The objective of this review was to analyse the risk factors that contribute to burden in informal caregivers of elderly patients with dementia. Methodology. A rapid review with systematic methodology was performed in the MEDLINE (PubMed), developing a search strategy (MeSH terms, keywords, and Boolean operators). Results. A total of 16 articles were included with different methodologies. Data were obtained about the degree of dementia in the elderly, caregiver profile and burden using the Zarit Burden Interview scale, and factors that affect suffering greater burden. It was observed that most of the caregivers are middle-aged women and that they cohabit with the elderly without consideration of the place of origin of the patient. Caregivers of patients with dementia are more burdened than caregivers of patients without dementia. Discussion. Caregivers with greater levels of stress and anxiety and lower than median knowledge of the disease scored worse on the Zarit Burden Interview scale. Attention should be focused on risk factors to avoid overload, and social, economic, emotional, and family support is also necessary.

Poesía y vida, visión de una futura enfermera

Las vivencias personales y los acontecimientos que se desarrollan a lo largo de la vida de un propio individuo inciden directamente en su personalidad y en la formación de su ser. Las adversidades de esta, marcan un punto de inflexión en el propio sujeto, en la toma de decisiones futuras y en su autoconstrucción, pues es importante destacar en estos puntos el término “gaman” que proviene de la cultura japonesa y cuyo significado recae en la forma o la postura de superación que adopta un propio ser frente a las adversidades o dificultades que se interponen en su vida[1]. El gaman se relaciona directamente con un término conocido en la sociedad occidental, la resiliencia: adaptarse a la adversidad y la capacidad de superar problemas o las situaciones que se imponen en la vida del individuo.

 

Por ello, el papel de enfermería como cuidador es la esencia de la profesión de enfermería, el cual se puede definir como: una actividad que requiere de un valor personal y profesional encaminado a la conservación, reestablecimiento y autocuidado de la vida que se fundamenta en la relación terapéutica enfermera-paciente (Juárez & García, 2009). La enfermería tiene el poder de influir en la forma en la que el individuo tome frente al obstáculo o adversidad que está viviendo, ayudándole así a alcanzar su meta.  Es importante en el papel del cuidado establecer al individuo como prioritario, centrándose así en el cuidado del paciente y no en paliar una patología o en búsqueda de soluciones, por ello, es fundamental desde el rol de enfermería, el cuidar escuchando, aceptando y sobre todo, validando los sentimientos de las personas.

 

Cabe destacar, el concepto de la Poesía del Cuidado, y para hablar de ella es necesario, previamente, clarificar sus relaciones con dos conceptos que inciden en su producción: arte y estética en el contexto de los cuidados (Siles & Solano, 2017). La más importante aportación de la poesía a la enfermería radica en la clarificación de su naturaleza transcendente mediante la revelación de su objeto sujeto, permitiendo reflexionar sobre los recuerdos y los olvidos (Siles & Solano, 2015).

 

El objetivo de este artículo es exponer mi propia línea de vida, conectando con mi propio ser y reflexionando sobre las vivencias que han ido sucediendo a lo largo de estos años pudiendo así identificar las experiencias más significativas han ocurrido, y de qué forma han influido y cambiado mi vida haciendo uso de la poesía del cuidado y como esta ha influenciado en mi vida desde la perspectiva de paciente y receptor del cuidado. Con este artículo se intenta evaluar la propia postura de la persona ante las adversidades y como las vivencias personales pueden influir en la vida de uno mismo, así como identificar y clarificar los sentimientos que nacen en consecuencia de lo vivido.

 

[1] Gaman es un término japonés derivado de la cultura budista zen. Significa "soportar lo aparentemente insoportable con paciencia y dignidad"(Ibarra, 2011)​ El término se traduce generalmente como "perseverancia", "paciencia", "tolerancia", o "abnegación" y está vinculado con el estoicismo y la resiliencia.

A standard procedure for constructing a multi-level social vulnerability index using CLSA and SOS data as working examples

by Jasmine C. Mah, Olga Theou, Mario Ulises Perez-Zepeda, Jodie L. Penwarden, Judith Godin, Kenneth Rockwood, Melissa K. Andrew

Background

The construct of social vulnerability attempts to understand social circumstances not merely as a descriptor, but as a predictor of adverse health events. It can be measured by aggregating social deficits in a social vulnerability index (SVI). We describe a standard procedure for constructing a multi-level SVI using two working examples.

Methods

First, we describe a six-step approach to constructing a SVI. Then, we conducted a secondary analysis of a clinical dataset (Canadian Immunization Research Network’s Serious Outcomes Surveillance Network (SOS)) and a population-based dataset (Canadian Longitudinal Study on Aging (CLSA)). In both datasets, we construct SVIs, use descriptive statistics to report distributions by age and sex, and perform a multivariable linear regression of social vulnerability on frailty.

Results

Procedures for drafting a list of candidate social items, selecting deficits for inclusion, and screening deficits to meet inclusion criteria were applied to yield a 18-deficit SVI for the SOS and 74-deficit SVI for the CLSA. Deficits in each SVI were re-scored between 0 and 1, where 1 indicates the greater risk. Finally, the sum of all deficits is calculated into an index. In the SOS, SVI was associated with age only for females and was weakly associated with frailty (r = 0.26, p Conclusion

We present a standard method of constructing a SVI by incorporating factors from multiple social domains and levels in a social-ecological model. This SVI can be used to improve our understanding of social vulnerability and its impacts on the health of communities and individuals.

Re-visioning of a Nursing Informatics Course With Translational Pedagogy

imageFor nurse leaders to excel in leadership roles in the clinical world of informatics, a comprehensive understanding of nursing informatics as translated within the broader scope of health informatics including clinical informatics and business intelligence is necessary. The translation of nursing informatics in the comprehensive scope of health informatics is not consistently taught in graduate nursing leadership curricula. Collaboratively, from an interprofessional education stance, a graduate nurse informatics course was re-visioned using translational pedagogy: the idea of teaching related concepts by translating each and vice versa. Specifically, we translated nursing informatics amid health informatics concepts including business intelligence. Leadership students in the re-visioned course experienced the ability to visualize, conceptualize, and understand how work in information systems impacts broader aspects of clinical and business decision-making. Looking at nursing informatics through the lens of health informatics will develop students' ability to visualize, conceptualize, and understand how work in information systems has an impact on the broader aspects of clinical decision-making and support. Further, this paradigm shift will enhance students' ability to utilize information systems in leadership decision-making as future knowledge workers.

Modelo de Bronfenbrenner en la prevención del embarazo adolescente

La adolescencia es un periodo de transición hacia la adultez, en la que se presentan cambios psicológicos, cognitivos y sociales, así como el inicio de su vida sexual, lo cual los predispone a originar una infección de transmisión sexual o un embarazo en la adolescencia. Se realizó un análisis del Modelo Ecológico de Bronfenbrenner en el papel que tiene el personal de enfermería en la salud reproductiva de los adolescentes. Al evaluar el contexto en el que las adolescentes, con riesgo de embarazo, en esa etapa se desarrollan, el Modelo Ecológico de Desarrollo Humano resulta relevante para identificar los factores de riesgo en el ambiente y en qué sistema le corresponde al personal sanitario, en especial, el personal de enfermería en la prevención de este problema de salud pública.

Multidimensional associations of physical performance, balance, wellness and daily activities with frailty in older adults with coexisting frailty and diabetes

Abstract

Background

The coexistence of frailty and type 2 diabetes mellitus in the older population heightens the risk of adverse events. However, research on functional and wellness factors associated with frailty in this population is limited.

Purpose

To investigate the associations of physical performance, functional dependency, physical activity, nutritional status, sleep, self-perceived health and depression with frailty in community-dwelling older adults with coexisting frailty and type 2 diabetes mellitus.

Design

Cross-sectional.

Methods

The study included 123 community-dwelling older adults (73.7 ± 6.0 years) with pre-frailty/frailty and type 2 diabetes mellitus. Physical performance (Short Physical Performance Battery), functional dependency (Barthel Index and Lawton & Brody), physical activity and inactivity (GeneActiv wrist-worn accelerometer), malnutrition risk (Mini Nutritional Assessment), sleep (Pittsburgh Sleep Quality Index), self-perceived health (EuroQoL 5-Dimension 3-Level) and depression (Yesavage 15-item-Geriatric-Depression-Scale) were evaluated through personal interviews. Principal component analysis (PCA) was performed to categorize the variables into components, and logistic regressions were used to propose the best-fitted model for each component.

Results

The PCA identified four components: (i) physical performance, with gait speed and leg mean velocity as the main variables associated with frailty; (ii) balance, showing significant associations with monopodal balance; (iii) daily activities, with moderate to vigorous physical activity and the Lawton and Brody score as the main variables associated with frailty within this component; and (iv) wellness factors, with nutritional status, self-perceived health and depression score as the primary variables associated with frailty.

Conclusions

This research underscores the significance of physical function and daily activities as protective factors against frailty in community-dwelling older adults with coexisting frailty and type 2 diabetes mellitus. The health dimension contributes both protective and risk factors, emphasizing the need for comprehensive assessments in managing frailty in this population.

Reporting Method

The study adhered to the STROBE checklist.

Patient or Public Contribution

No patient or public contribution.

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