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Patient safety is important when evaluating a healthcare organization's ability to control and eliminate patient dangers when implementing evidence-based practice (EBP). There is limited understanding of how EBP affects safety culture.
The purpose of this study was to assess nurses' perceptions of EBP utilization and its effect on patient safety culture.
A cross-sectional, descriptive design was employed utilizing self-report questionnaires. A convenience sample of 381 registered nurses was recruited from four major hospitals in Jordan. Descriptive and multivariate linear regression analyses were used.
EBP knowledge/skills had the highest positive score. Meanwhile, organizational learning and continuous improvement were the greatest positive scores of patient safety culture among nurses. Nurses who perceived greater knowledge/skill associated with EBP reported higher levels of organizational learning and continuous improvement (β = 0.15, p < 0.001), increased teamwork within units (β = 0.11, p < 0.05), lower perceptions of nonpunitive responses to error (β = −0.15, p < 0.001), greater communication openness (β = 0.16, p < 0.001), and improved feedback and communications about errors (β = 0.13, p < 0.01).
The association between EBP and patient safety underscores the importance of systematically implementing EBP in healthcare settings. As scientific evidence informs clinical practice, it is crucial for hospitals to integrate EBP into their policies and strategies to sustainably foster a culture of safety and optimize nursing practices.
Burns are a major cause of morbidity in Yemen, and their prevention relies heavily on community knowledge and safe practices. Understanding gaps in awareness and behaviour is essential for designing effective interventions. This study assessed the knowledge, attitudes and practices (KAP) regarding burn prevention and first aid among a Yemeni community. A cross-sectional survey was conducted among 380 participants using a structured questionnaire distributed via social media and community networks. Data were collected on demographics, educational level, occupation, residential area and KAP related to household, electrical and chemical burns. Associations between participant characteristics and burn-related KAPs were analysed. Participants were predominantly female (63.7%), aged 15–45 years (79.8%), urban residents (92.9%) and university-educated (82.1%). Healthcare workers comprised 50.8% of respondents. Knowledge of burn prevention and first aid was highest among university-educated and healthcare participants, with 84.6% correctly identifying initial burn management. Unsafe practices, such as applying honey or toothpaste and improper handling of chemical or electrical injuries, were more common among less-educated, rural and nonhealthcare respondents. Urban participants demonstrated better preventive practices, while cultural reliance on traditional remedies persisted across all groups. Among predominantly urban and educated populations in Yemen, knowledge and attitudes toward burn prevention and first aid are generally favourable; however, gaps persist, particularly in rural and less-educated communities. Cultural practices and misconceptions continue to limit optimal care. These findings underscore the urgent need for culturally sensitive, literacy-appropriate, community-based interventions to improve burn prevention, first aid practices and equitable health outcomes.
The aim of this paper is twofold: (1) to introduce a phenomenological-hermeneutic approach and discuss its application within the context of WSs in the field of health science, (2) To present a method and a practical guide when conducting WSs in the field of health science.
Epistemological and methodological discussions based on workshops as a self-standing research method.
The epistemological and methodological discussions show that workshops conducted in health science are a self-standing research methods and align with a phenomenological-hermeneutical approach. Examples of research studies within this framework are provided to illustrate how workshops can be conducted in health science within this epistemological approach.
The phenomenological-hermeneutical approach embraces workshops as a research method as it includes individual experiences through self-reflection and shared contributions through interpretation. Furthermore, a systematic approach with regard to planning, conduction, data collection, and data analysis leads to reliable findings, enhancing the transparency of the research method and thus creating scientific knowledge. This paper argues that the systematic approach of “the how” to conduct workshops with “the why” enhances the transparency and trustworthiness of the research.
Workshops are a way to involve and engage users in co-design processes that aim to develop solutions in clinical practice. User involvement has become an important part in academia and is essential in all aspects of the research process. However, we need solid systematic methods to create valid knowledge. Workshops are a self-standing research method, and a phenomenological-hermeneutical approach allows for an understanding of the phenomena as they unfold, emphasising subjective perceptions and meanings, which will finally lead to the development of a suitable solution for clinical practice.
This paper contributes theoretical knowledge about the use of workshops as a research method. It combines “the how” to conduct a workshop with “the why” and highlights the relevance of a phenomenological-hermeneutical approach. The main argument is that workshops are a self-standing research method; hence, this paper adds value in the academic field as it provides a scientific framework. The paper presents a method and a practical guide for researchers who plan to conduct workshops in the field of health science.
No available EQUATOR guidelines were applicable to this methodological paper because no new data was created or analysed.
This is a methodological paper, and thus, there was no direct patient or public involvement.
by Heba Ghozlan, Saja Al-Malahmeh, Othman Al-Shboul, Anas J. Mistareehi, Lina Elsalem
Store-operated calcium entry (SOCE), mediated by ORAI1–3 calcium channels and stromal interaction molecules STIM1 and STIM2, is increasingly recognized as a regulator of cancer progression. However, its role in head and neck squamous cell carcinoma (HNSCC) and its relationship with major oncogenic pathways remain poorly defined. Transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) were analyzed to profile isoform-specific ORAI1–3 and STIM1–2 expression across HNSCC subtypes and oncogenic contexts. In parallel, the effects of pharmacologic SOCE inhibition with 2-aminoethoxydiphenyl borate (2-APB) were evaluated in FaDu (epidermal growth factor receptor [EGFR]-high, PIK3CA–wild-type) and Detroit-562 (metastatic, PIK3CA–mutant) cells by assessing viability, migration, and clonogenic survival. TCGA analysis revealed a context-dependent SOCE expression profile. ORAI1–3 and STIM2 were broadly upregulated in tumors, while STIM1 was significantly downregulated, particularly in advanced and basaloid subtypes. PIK3CA mutations, especially the H1047R hotspot, were associated with higher STIM1 expression, whereas EGFR expression correlated positively with STIM1/2 but negatively with ORAI1/3. In vitro, Detroit-562 cells expressed higher levels of SOCE components and showed greater sensitivity to SOCE inhibition, with marked reductions in viability, migration, and clonogenic capacity. FaDu cells, despite higher EGFR expression, exhibited lower SOCE gene expression and relative resistance to 2-APB, which suggests reduced dependence on SOCE-mediated signaling. These findings suggest that SOCE components are transcriptionally dysregulated in HNSCC and may represent a context-dependent therapeutic vulnerability, particularly in PIK3CA-mutant tumors. Validation in additional preclinical models, patient-derived xenografts, and clinical specimens is required to establish SOCE as a biomarker and therapeutic target in HNSCC.by Shamal Ali Othman, Dalshad Kakasor Ismael Jaff, Ahmet Öztaş
Construction projects are exposed to numerous risks that may adversely affect project cost and duration. The purpose of this study is to identify and prioritize key construction risks by combining a Work Breakdown Structure (WBS) with a Risk Breakdown Structure (RBS) and analyzing these risks using two-dimensional (2D) and three-dimensional (3D) risk matrices. In total, 63 risk factors were identified and categorized into five main areas of the work breakdown structure: earthwork, concrete, finishing, mechanical, and electrical. The questionnaire was designed based on each risk category and then sent to engineers, who were asked to estimate the risk probability and its impact. In total, 378 engineers responded. The respondents data were analyzed by using the risk matrix method. Two separate 3D risk matrices were made: one was based on multiplying all three data points, and the other was based on combining both impacts. The results clearly show that the 3D matrix, which combines cost and time impact, yields more accurate results than the matrix that multiplies cost impact and time impact.To identify predictors of treatment changes and to evaluate the effectiveness and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) initiating tofacitinib in a real-world setting.
The non-interventional study ESCALATE-RA included 1518 patients with RA from Germany. RA treatment, including all changes in therapy, was documented for 24 months starting from the initial intake of tofacitinib.
All patients started with tofacitinib therapy, either as monotherapy or in combination with methotrexate (MTX).
The impact of several factors of interest on the number and timing of treatment changes was assessed as primary outcome using Cox proportional hazards models. Further outcomes were tofacitinib drug survival and the use of follow-up disease-modifying antirheumatic drugs after first treatment change. We also assessed the effectiveness, concomitant glucocorticoid (GC) use, PROs (such as functional ability, patient satisfaction, pain and quality of life) and safety. Analyses were based on observed data.
‘Lack of efficacy’ (HR 3.30) and ‘intolerance’ (HR 4.43) leading to termination of tofacitinib were key factors favouring therapy changes. Higher patient satisfaction was significantly associated with a reduced likelihood of treatment changes (HR 0.82). Increasing GC doses were associated with a higher probability of step-up/switch changes (HR 1.21). The estimated tofacitinib drug survival was 48% at the end of study. Proportions of patients achieving low disease activity (both Simplified Disease Activity Index (SDAI) and Clinical Disease Activity Index (CDAI) 62%) and remission (SDAI 25%, CDAI 28%) increased from baseline under tofacitinib and were comparable between monotherapy and combination therapy with MTX. Mean concomitant GC dose decreased (2 mg/day). PROs indicated reduced pain and fatigue, while functional ability and quality of life improved. 63.9% of the patients experienced a treatment-emergent adverse event (AE), 8.8% a treatment-emergent AE of special interest and deaths occurred in 0.5%.
Key factors for therapy changes in patients with RA treated with tofacitinib were lack of efficacy and intolerance. Higher patient satisfaction was associated with a reduced probability of treatment changes, while increased GC doses led to a higher likelihood of step-ups/switches. Patients demonstrated a marked reduction in disease activity for up to 24 months, along with improvements in functional ability, pain and quality of life. Observed AEs were consistent with the known safety profile of tofacitinib.
To assess the preliminary effectiveness and cost-effectiveness of a culturally tailored, music-based broadcast intervention delivered through schools and community radio to improve referral adherence among schoolchildren to inform the need for a definitive trial.
Pilot randomised interventional study.
18 schools across Unguja and Pemba islands, Zanzibar.
Schoolchildren (6–18 years old) who failed vision screening and were referred for care recruited from January to February 2024. The registered sample size reflects the full cohort, including children and adults. This manuscript reports on the child cohort only, as per the predefined analysis plan.
Group 1 received 3 months of school-based broadcasts of culturally tailored 3–6 min songs (played three times daily on 2 days per week), followed by 3 months of community radio broadcasts of additional songs (3–6 min, aired three times daily); Group 2 received the community broadcasts during the same period as Group 1.
The primary outcome was change in referral adherence assessed at two time points: 3 months after school broadcast and 3 months after community broadcast, expressed in difference-in-difference estimates and effect sizes. Secondary outcomes included reporting of adverse events and contamination, and cost-effectiveness calculated as cost per child reached and cost per referred child accessed care in study groups and combined intervention.
374 children were referred to eye care services, including 246 in Group 1 and 128 in Group 2. Referral adherence was 69.8% in Group 1 and 42.9% in Group 2 (p=0.0006). The school broadcast phase yielded an effect size of 0.26 and a cost of US$4.65 per referred child accessing services. The community broadcast produced an effect size of 0.21, with a cost of US$0.29 per person reached. The combined intervention reached individuals at a cost of US$0.37 per person. No adverse event and contamination was reported.
A combined school and community broadcast intervention improved referral adherence in this pilot trial, with evidence of cost-effectiveness. These findings support the conduct of a fully powered definitive trial.
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