Conectar
Commentary on: Considine J, Casey P, Omonaiye O, et al. (2024). Importance of specific vital signs in nurses' recognition and response to deteriorating patients: A scoping review. Journal of Clinical Nursing, 00, 1–18.
Implications for practice and research There is a need to develop training and protocols that will enhance nurse’s documentation and utilisation of vital signs in clinical decision-making and patient care. To further guide the creation of training curricula and standards, future studies should examine how nurses prioritise and make decisions about vital sign assessments and their use in patient care.
Vital signs are essential markers of a patient’s physiological state, and these include heart rate, temperature, blood pressure, oxygen saturation, respiration rate and level of consciousness. Consequently, accurate assessment, documentation and interpretation of these markers are vital for early detection of patients’ deterioration and timely intervention.
To examine clinical nurses' attitudes towards and self-reported experiences of family nursing in Japan following the relaxation of COVID-19 visitation restrictions. Particular attention is paid to early career nurses whose formative training occurred during visitation bans. The study focused on nurses' negative perceptions and emotional burdens associated with family involvement.
A quantitative-dominant mixed-methods cross-sectional study reported in accordance with the STROBE guideline.
Using a convenience sampling approach, a self-administered, paper-based questionnaire was distributed to clinical nurses in four general hospitals in Japan between January and May 2024. The questionnaire consisted of four parts: demographic and professional background, learning methods related to family nursing, 17 items including negatively valenced statements adapted from the Families' Importance in Nursing Care–Nurses' Attitudes (FINC-NA) scale, and one open-ended question. Quantitative data were analysed using descriptive statistics and t-tests, and qualitative responses were thematically analysed.
Of 1921 nurses invited, 957 responded (response rate: 49.8%), and data from 892 valid responses were analysed. Overall, the nurses demonstrated positive recognition of family nursing as a professional value but also reported lingering emotional burdens and practical challenges when interacting with families. Early-career nurses who began practice during the pandemic showed greater uncertainty and lower affective engagement. Thematic analysis revealed five key themes: relational disruption, emotional stress, moral conflict, reappraisal of family engagement and ongoing barriers.
The findings underscore the need to structurally and educationally reintegrate families into nursing care. Simulation-based training, clear institutional policies and hybrid communication models are essential to rebuild relational continuity and support nurses' emotional and ethical capacity for family nursing.
The findings highlight the need to structurally and educationally reintegrate families into clinical care to address the emotional burden and ambivalence reported by nurses. Organisational support—such as clear visitation policies, simulation-based education and reflective opportunities—can help rebuild nurses' relational competence and confidence in engaging with families. Creating supportive learning environments, including on-the-job mentoring and team-based reflection, may further facilitate the restoration of family nursing.
This study addressed how prolonged COVID-19 visitation restrictions disrupted family nursing practice in Japan, created generational differences in nurses' competencies, and shaped nurses' perceptions of family involvement. Nurses reported emotional strain, feelings of being monitored and lack of time when families were present. Early career nurses showed lower relational engagement, while experienced nurses expressed moral distress. ‘Latent indifference’ was also noted. The findings provide valuable insights for healthcare organisations, nurse educators and policymakers by informing strategies to reintegrate families into patient care, improve discharge planning and strengthen training models.
The STROBE checklist.
No patient or public contribution.
by Azusa Kubota, Kentaro Kojima, Shinnosuke Koketsu, Takayuki Kannon, Takehiro Sato, Kazuyoshi Hosomichi, Yoshiaki Shinohara, Atsushi Tajima
Brain asymmetry is a fundamental feature of neural organization. However, the molecular basis of hippocampal lateralization in response to environmental stimuli remains poorly understood. Here, we examined the transcriptomic profiles of the left and right hippocampal CA1 regions in rats reared under isolated or enriched housing conditions to elucidate hemisphere-specific responses and shared molecular adaptations. RNA-sequencing analysis revealed lateralized differences in the number and identity of differentially expressed genes, accompanied by distinct biological themes, as indicated by overrepresentation and gene set enrichment analysis. The left CA1 region was prominently engaged in pathways related to synaptic organization and mitochondrial function, whereas the right CA1 region exhibited enrichment in transcriptional regulation and RNA metabolic processes. Despite these asymmetries, co-expression and protein–protein interaction network analyses revealed shared molecular architectures. Immediate early genes formed consistent central hubs across both hemispheres, and a common Mecp2–Grin2b–Cdkl5–Tet3 protein interaction cluster was identified as a potential integrative regulatory module. Additional enrichment analysis of differentially expressed genes shared between hemispheres further highlighted conserved responses, particularly in synaptic plasticity and cell–cell communication. Together, these findings demonstrate that the left and right CA1 regions employ distinct yet partially convergent transcriptional programs to adapt to environmental stimuli. This coordinated molecular asymmetry provides novel insights into hippocampal lateralization and its role in experience-dependent brain plasticity.To create a healthy nursing environment and protect human health in response to climate change, it is essential to encourage behaviour change among nurses. Although numerous studies have been conducted on nurses to address climate change, few studies have explored the relationships of factors that influence and promote nurses' climate health behavioural behavioural change, making it difficult to determine how nurses should act and prioritise regarding climate health behaviours.
To investigate influential environmental factors on climate health behaviours among nurses through the causal relationships between environmental information, environmental beliefs and environmental self-efficacy using the Information-Motivation-Behavioural Skills (IMB) model.
A cross-sectional study.
This study recruited 186 nurses working in hospitals nationwide in July 2023. Self-reported questionnaires (Climate, Health, and Nursing Tool; National Environmental Consciousness Survey; New Ecological Paradigm Scale; Personal Efficacy Scale) were used to collect the data. Path analysis was performed.
The factors influencing nurses' climate health behaviours were environmental information, environmental beliefs and environmental self-efficacy. Environmental self-efficacy was found to be more influenced by the exogenous variables of environmental information than environmental beliefs and to be the most significant factor affecting climate health behaviours.
It is more important for nurses to obtain environmental information than environmental beliefs to achieve the goal of climate health behaviours. This in turn, will lead to personal self-efficacy that nurses can mitigate the climate crisis. Their strong self-efficacy affects their climate health behaviours.
Nurses should seek and draw on the appropriate environmental information related to climate health change and nurses with environmental self-efficacy become environmental nursing leaders, encouraging other health care workers to participate actively in climate health behaviours and continuously carry out the behaviours within daily life, hospital and community environments.
The study addressed the lack of relationship research on factors influencing nurses' climate health behaviours, emphasizing the importance of accessing environmental information to foster self-efficacy. Nurses with heightened self-efficacy can lead healthcare professionals in climate health actions.
This research has adhered to relevant EQUATOR and STROBE.
No Patient or Public Contribution.
by Daisuke Hiraoka, Jun Ishizaki, Kenta Horie, Kensuke Oryoji, Shin-ichi Mizuki, Katsuto Takenaka
ObjectivesTo investigate the relationship between Human Leukocyte Antigen-DR beta 1 (HLA-DRB1) shared epitope (SE) alleles and peripheral blood monocyte counts in disease-modifying antirheumatic drug-naïve patients with rheumatoid arthritis (RA), and also the relationship between specific SE alleles and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) titers.
MethodsThis retrospective single-center study included 86 Japanese patients with RA. HLA-DRB1 genotyping was performed, and SE alleles associated with a high risk of developing RA were classified into the S2 (*04:01) and S3P (*01:01, *01:02, *04:04, *04:05, *04:08, and *10:01) categories. Patients were stratified based on monocyte count tertiles. The relationships between monocyte counts at diagnosis and clinical, serological, and genetic factors were analyzed. Logistic regression was used to identify independent factors associated with high monocyte counts.
ResultsSE-positive patients, particularly those with S3P alleles, had significantly higher monocyte counts than SE-negative patients. A multivariate analysis revealed that male sex and S3P positivity, particularly HLA-DRB1 *01:01 or *04:05, were independently associated with higher monocyte counts. Patients carrying at least one S3P allele had significantly higher anti-CCP Ab titers, with patients homozygous for HLA-DRB1 *04:05 having the highest levels. A similar relationship was not found with HLA-DRB1 *01:01 despite its strong effect on monocyte counts.
ConclusionsThis is the first study to demonstrate a significant association between SE alleles and peripheral blood monocyte counts in RA. The results obtained suggest that specific SE alleles, particularly S3P alleles, contribute to the early pathogenesis of RA by enhancing monocyte-driven immune activation and anti-CCP Ab production.
by Xu Jia, Jiaojiao Peng, Junhong Lv, Yuanting Li, Ziren Luo, Jing Xiang, Yaqin Hou, Qian Zheng, Bin Han
The presence of substantial quantities of antibiotics and their metabolites in hospital wastewater can lead to the accumulation of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs). Research on the influent and effluent sewage of hospitals is crucial for understanding the effectiveness of wastewater treatment systems in inactivating ARB and ARGs. Key features of microbial communities and ARGs in influent and effluent wastewater – including taxonomic diversity and relative abundance – were assessed via metagenomic sequencing. The treatment process resulted in a reduction of the overall bacterial count in hospital wastewater. However, a notable increase in relative abundance was observed for three phyla, 16 genera, and 21 species post-treatment. Bacteria harboring ARGs were predominantly identified as belonging to Pseudomonadota and Bacillota. A total of 354 ARGs were detected in the influent, while 331 were identified in the effluent samples, with a general decrease in absolute abundance. Nevertheless, the relative abundance of certain ARGs, such as mphG, fosA8, and soxR, was found to increase in the effluent across all samples. Seasonal fluctuations also played a role in the distribution of microbial communities and ARGs. These findings underscore the role of hospital wastewater treatment systems in reducing the discharge of ARB and ARGs into the environment, while also revealing potential shortcomings in the wastewater treatment process that necessitate further improvement for more effective removal of these ARGs.by Xiaojing Gong, Dingshan Xue, Hongyan Meng, Bing Xie, Lihua Zhao, Chuanhui Zang, Jingjing Kong
BackgroundInflammation is a critical immune response that protects the body from infections and injuries. However, chronic inflammation can lead to diseases such as cancer. Curcumin, a bioactive compound extracted from Curcuma longa, has been widely studied for its anti-inflammatory properties. Despite extensive research, the comprehensive molecular mechanisms underlying curcumin’s anti-inflammatory effects, particularly its multi-target regulatory network, remain incompletely understood. This study aims to elucidate these mechanisms using an integrated approach combining network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experimental validation.
MethodsWe utilized network pharmacology to identify potential targets and pathways involved in curcumin’s anti-inflammatory effects. Molecular docking and dynamics simulation were conducted to evaluate the binding affinity and stability of curcumin with key inflammatory targets. The anti-inflammatory effects of curcumin were further validated in vitro using LPS-induced RAW 264.7 cells. Cell viability, NO content, and mRNA expression levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF) were assessed.
ResultsNetwork pharmacology identified 135 potential targets for curcumin’s anti-inflammatory effects, with key pathways including TNF, HIF-1, PI3K-Akt, JAK-STAT, and MAPK signaling pathways. Molecular docking revealed strong binding affinities of curcumin with core targets such as IL-6, TNF, IL-1β, AKT1, and STAT3, with binding energies ranging from −6.2 to −7.5 kcal/mol. Molecular dynamics simulations demonstrated the stability of these complexes over a 100-nanosecond period. In vitro experiments showed that curcumin significantly reduced NO production and mRNA expression of IL-1β, IL-6, and TNF in LPS-induced RAW 264.7 cells, with optimal effects observed at a concentration of 125 μg/mL.
ConclusionOur study provides a comprehensive understanding of curcumin’s anti-inflammatory mechanisms through an integrated approach. The findings highlight curcumin’s potential as a therapeutic agent for inflammatory diseases. However, further in vivo studies are necessary to fully elucidate its therapeutic efficacy and mechanisms of action.
The intestinal microbiota of people with Parkinson’s disease (PwP) differs significantly from that of healthy individuals. Given that altered microbiota may play a role in the pathogenesis of Parkinson’s disease, faecal microbiota transplantation (FMT) has been proposed as a potential therapeutic approach. However, the efficacy of FMT in improving motor symptoms in PwP has been inconclusive in some pilot randomised controlled trials (RCT). Previous RCTs on PwP employed simple FMT, but our modified approach—pretreatment with antibiotics before FMT (A-FMT)—has been shown to improve the engraftment rate of given species and the beneficial effects of FMT. This study aims to evaluate the efficacy and safety of A-FMT for PwP, particularly in those with motor fluctuations.
This study is a randomised, double-blind, placebo-controlled, parallel-group study with an 8-week observation period following a single A-FMT. Thirty clinically established PwP with prominent motor fluctuation episodes will be randomised 1:1 to FMT or placebo. Participants in both groups will receive antibiotic treatment prior to colonoscopy for FMT or placebo treatment. Primary and secondary endpoints will include subjective and objective evaluations of motor and non-motor symptoms and will be evaluated before and after antibiotic treatment and at 4 and 8 weeks after the procedure. Exploratory endpoints will include blood and faecal sample analyses, advanced brain MRI and pharmacokinetic assessment of levodopa concentrations during a levodopa challenge test.
This study has been approved by the ethical committee of Juntendo University in August 2024 (J24-005) and will be conducted in accordance with the Declaration of Helsinki, the Japan Ministry of Health, Labour and Welfare Clinical Trials Act and related laws and regulations. All patient data will be anonymised to protect privacy and used solely for study purposes. Results will be published in academic journals and presented at conferences.
jRCTs031240344.
Commentary on: Perrella A, Geen, O, Ahuja, M, et al. Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials. Critical Care Med. 2024 September. doi: 10.1097/CCM.0000000000006315
Implications for practice and research More information on how age, frailty, and multimorbidity affect responses to interventions in critically ill older adults would be important and beneficial for shared decision-making. Future studies should focus more on these understudied populations of older patients with frailty or multimorbidity and examine how they respond to intensive care unit interventions.
Recent data show that there has been an increase in the older populations admitted to intensive care unit (ICU).
To assess career satisfaction among Chinese nurses, explore influencing factors, and examine the mediating role of role breadth self-efficacy (RBSE) in the relationship between subjective age and career satisfaction.
A multi-centre, cross-sectional study.
Between June and October 2024, 2033 questionnaires were distributed to nurses across seven geographic regions in China, collecting data on demographics, subjective age, RBSE, and career satisfaction. Descriptive statistics, Pearson correlation analysis, multiple linear stepwise regression, and path analysis were used to identify determinants of career satisfaction and test the mediating effect of RBSE.
The effective response rate was 97%. Chinese nurses reported moderate-to-high career satisfaction, younger subjective age relative to chronological age, and moderate RBSE levels. Multivariate linear regression analysis identified education level, work institution, salary, weekly working hours, subjective age, and RBSE as significant predictors of career satisfaction. Path analysis revealed a significant negative association between subjective age and career satisfaction (β = −0.23, p < 0.001), which was partially mediated by RBSE (indirect effect = −0.11, 95% CI: −0.18 to −0.05).
The career satisfaction of Chinese nurses is at a moderately high level; the influencing factors include the intensity of nursing work and salary levels. There is a certain difference between the subjective age and the chronological age of Chinese nurses. RBSE partly mediates the relationship between subjective age and career satisfaction.
Valuing the breadth of nurses' roles, self-efficacy, and subjective age may help improve job satisfaction.
What problem did the study address?: This study elucidates the present level of career satisfaction among nurses in China and the variables affecting it. What were the main findings?: The subjective age of Chinese nurses influences career satisfaction, with RBSE partly mediating the connection between subjective age and career satisfaction. Where and on whom will the research have an impact?: This study presents novel variables of subjective age and RBSE in the investigation of factors influencing career satisfaction among Chinese nurses, offering new avenues for enhancing career satisfaction in this demographic in the future.
We adhered to STROBE guidelines for cross-sectional research.
This study did not include patient or public involvement in its design, conduct, or reporting.
To conceptualise information distortion in Electronic Health Records (EHRs), with the goal of providing a theoretical foundation for improving documentation practices.
A concept analysis.
Walker and Avant's strategy for concept analysis was used. The defining attributes, antecedents and consequences were identified.
A comprehensive search was conducted across PubMed, Web of Science, Embase, CINAHL and Scopus from their inception to December 2024. Studies published in English that addressed information distortion in EHRs were included.
A total of 37 studies were included. The three defining attributes were: real-world health truth, representation of reality and mismatch relationship. Antecedents were divided into five categories: people-related factors, equipment factors, regulatory factors, working environment factors and management factors. The consequences of information distortion in EHRs included threats to patient safety, poor operational performance, eroded trust, compromised research quality and health inequity.
This concept analysis enhances the understanding of information distortion in EHRs and provides a foundation for further empirical validation. The findings may contribute to the development of measurement instruments and strategies to mitigate information distortion in healthcare settings.
By undertaking a concept analysis of information distortion in EHRs, healthcare professionals will be better equipped to recognise and assess this ethical phenomenon, thereby supporting the development of targeted interventions to mitigate potential harms to healthcare practices. In addition, the clarity of this concept could provide a new angle from which to analyse the origins of flawed EHR documentation and its ripple effects across healthcare systems.
No patient or public involvement.
This study aimed to investigate the associations between body mass index (BMI), physical activity levels (PALs) and sociodemographic factors (gender, age, education and marital status) with different outcomes (symptoms) of osteoarthritis (OA) severity, in patients with knee OA.
Cross-sectional study.
The sample included 200 participants from southern Bosnia and Herzegovina (61 males, 65.1±9.01 years of age) who had been diagnosed with primary knee OA.
OA symptoms as evidenced by the Western Ontario and McMaster Universities OA Index (WOMAC) scale, including three subscores (WOMAC-pain, WOMAC-stiffness, WOMAC-functionality) and total WOMAC score. The predictors included age (in years), gender (male or female), BMI, PAL, education level, urban/rural living environment and marital status (partnership).
Female gender was correlated with the WOMAC-pain, WOMAC-stiffness and WOMAC-total. Older age was correlated with the WOMAC-pain and WOMAC-total. Patients who were better educated and reported higher PAL had better WOMAC functionality. BMI was the most significant factor of influence, with higher WOMAC-pain (OR 1.44, 95% CI 1.27 to 1.65), WOMAC-stiffness (OR 1.20, 95% CI 1.1 to –1.33), WOMAC-functionality (OR 1.26, 95% CI 1.13 to 1.40) and WOMAC-total (OR 1.29, 95% CI 1.6 to –1.44) scores in patients with higher BMI.
Results indicate the necessity of controlling body weight in patients with diagnosed knee OA irrespective of gender. Further prospective studies are warranted in order to establish causality between variables.
Traumatic brain injury (TBI) often causes permanent neurological dysfunction. Although no medication has been validated yet to prevent secondary injury of brain tissue, recent animal studies have reported that perampanel, a glutamine receptor antagonist, could improve the neurological functions of animals with TBI by mitigating the abnormal calcium influx and cell death around the site of primary injury. The present study aims to elucidate the efficacy of perampanel administration in improving the neurological function of patients with TBI.
The perampanel for alleviation of secondary injury in TBI trial is a multicentre, phase-II, open-label randomised controlled trial targeting patients with mild-to-moderate TBI. This trial will include adult TBI patients with a Glasgow Coma Scale score of 9–14 from five tertiary centres. Patients with epilepsy as a comorbidity, delayed presentation of symptoms (>24 hours after injury) or Injury Severity Score of ≥25 will be excluded. The study participants will be randomly assigned to either the perampanel group (2 mg/day) or the control group (fosphenytoin administered at a dose of 15–18 mg/kg/day, followed by 5–7.5 mg/kg/day of fosphenytoin). In both groups, the medication will be initiated within 12 hours of the TBI diagnosis and continued for 7 days. The antiepileptic drugs can be increased, changed or added as necessary if early post-traumatic seizures are observed. The primary outcome is favourable neurological outcome, defined as a Glasgow Outcome Scale Extended score of ≥5 at 90 days after the TBI diagnosis, which will then be compared between the groups through an intention-to-treat analysis.
The present study has been approved by the Certified Review Board of Keio at the principal institution (approval number: N20240004). Written informed consent will be obtained from all participants or their legal representatives. The results will be disseminated via publications and presentations.
Japan Registry of Clinical Trials (jRCTs031250067).
To (1) examine the attitudes of community-dwelling adults towards death and their ability to cope with death, as well as (2) understand the influence of advance care planning on community-dwelling adults' death attitudes and coping with death.
A sequential explanatory mixed-methods study was conducted in Singapore.
In Phase I, a case–control study was conducted to examine the differences in death attitudes and coping with death ability between community-dwelling adults who have completed advance care planning and those who have not. A univariate general linear model was used to compute the mean difference in death attitudes and coping with death scores. In Phase II, a descriptive qualitative study was conducted to provide an in-depth understanding of the influence of advance care planning among community-dwelling adults. Thematic analysis was used for qualitative analysis. Mixed-methods analysis was conducted to integrate the quantitative and qualitative data.
In Phase I, 80 community-dwelling adults who had completed advance care planning and 81 community-dwelling adults who did not have advance care planning were included. Adults who had completed advance care planning had significantly higher coping with death scores (t = 4.14, p < 0.01). In Phase II, a purposive sample of 24 adults who had completed advance care planning was selected for individual semi-structured interviews. From the thematic analysis, three themes were developed: (1) Advance care planning enables coping with death, (2) overcoming fear of death with advance care planning and (3) confronting death with advance care planning.
Advance care planning may influence death attitudes and coping with death. Further work on longitudinal designs and among individuals from different age groups should be used to gain further in-depth understanding of the impacts of advance care planning.
Strategies to enhance one's coping abilities with death and death attitudes should be developed to stimulate the uptake of advance care planning.
This paper was reported according to the Good Reporting of A Mixed Methods Study framework.
Community-dwelling adults participated in the survey and interviews.
To evaluate the effectiveness of nurse-led care (NLC) in patients with rheumatoid arthritis on disease activity, physical function, fatigue, satisfaction, pain, and quality of life.
Rheumatoid arthritis is a chronic autoimmune disease, which may not respond to insufficient rheumatology care capacity and workforce shortage. NLC is a care delivery model that can help address this shortage and improve disease management.
Systematic review and meta-analysis.
Nine databases were independently searched by two reviewers for eligible studies. Randomised controlled studies evaluating the effects of NLC on disease activity, physical function, fatigue, satisfaction, and other outcomes were included. The cochrane risk of bias tool was used to assess the risk of bias.
A total of nine studies involving 1447 participants were included. The pooled results indicated that no significant difference in disease activity was found at 0.5 years of follow-up (SMD: −0.33, 95% CI [−0.70, 0.04]), and a significant difference was seen in favour of NLC at 1 year (SMD: −0.35, 95% CI [−0.48, −0.10]), and 2 years (SMD: −0.29, 95% CI [−0.48, −0.10]). Moreover, no significant difference was found in fatigue and satisfaction at 0.5 years of follow-up, whereas differences in favour of NLC were seen at 1 year. In addition, no significant difference was found in physical function, pain, and quality of life.
This review indicated that NLC was not inferior to other types of care, and even had a better positive impact on disease activity, fatigue, and satisfaction for patients with rheumatoid arthritis.
Our study demonstrates that NLC is an effective approach to managing rheumatoid arthritis and recommends medical practitioners be well-versed in its importance.
Patients or public members were not directly involved in this study.
ClinicalTrials.gov identifier: CRD42022355963
This study observed changes in respiratory rate measurement (RRM) and identified barriers and challenges in clinical practice that influence healthcare worker behaviour, aiming to improve RRM in a hospital setting.
An observational study was conducted.
We observed and analysed changes in the behaviour of healthcare workers at a hospital where multi-nudges were introduced to improve RRM.
We checked respiration rate using electronic data and discovered that the original measurement rates were low. Measurement rates rapidly increased after posters were added. Barriers such as time constraints and measurement equipment were also noted.
RRM was found to be effective in promoting behavioural economics in medical settings. The results show that incorporating behavioural science principles into medical interventions has the potential to positively change behaviour.
By increasing nurses' awareness of respiratory rate measurement and addressing barriers to it, the measurement rate of respiratory rate can also increase, leading to more accurate patient evaluations and triage.
The proportion of respiratory rate measurements leading to rapid response system (RRS) calls was low.
The study observed that a multi-nudge approach effectively changes the behaviour of ward nurses, resulting in enhanced quality of medical care.
This research can serve as a valuable reference for leaders promoting healthcare quality projects, by offering a method to encourage behavioural change.
This study complied with the EQUATOR guidelines and its reporting adheres to the STROBE checklist.
No patient or public contribution.
Family-centered care is an approach to promote the health and well-being of children with chronic diseases and their families. This study aims to explore the knowledge components, structures, and research trends related to family-centered care for children with chronic conditions. We conducted the keyword network analysis in three stages using the keywords provided by the authors of each study: (1) search and screening of relevant studies, (2) keyword extraction and refinement, and (3) data analysis and visualization. The core keywords were child, adolescence, parent, and disabled. Four cohesive subgroups were identified through degree centrality. Research trends in the three phases of a recent decade have been changed. With the systematic understanding of the context of the knowledge structure, the future research and effective strategy establishment are suggested based on family-centered care for children with chronic disease. 
FreshRSS 