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Construction of a public health emergency information system framework: A case study of Zhuhai city, China

by Sicheng Huang, Xuebao Zhang, Long Chen, Xihe Ni, Ying Fan, Chaomin Zhao, Junfeng Xiao, Feng Ruan

Background

A public health emergency information system serves as a critical tool for collecting and analyzing data from sudden public health events, thereby providing a scientific basis for governmental decision-making. However, research on the systematic construction of such information system frameworks within China’s public health infrastructure is lacking.

Objective

Taking Zhuhai city as a case study, this study aims to construct a comprehensive public health emergency information system framework applicable to public health departments at the municipal, county, and street/township levels.

Methods

First, through a literature review and expert group discussion, the preliminary framework of system indicators is determined. Second, through two rounds of the Delphi method, 41 experts are invited to qualitatively select the system framework indicators, with the aim of obtaining consensus among experts. Finally, the system is improved through application, feedback, and redesign.

Results

After two rounds of consultation, the final system at the city and county levels consists of 5 first-level indicator modules and 21 second-level indicator modules, whereas the system at the city, county, and street/township levels consists of 4 first-level indicator modules and 17 second-level indicator modules. Most of the indicators in the “emergency preparedness” and “emergency response” modules are considered important and should be retained as they can play a role in collecting and analysing information on infectious disease outbreaks through practical applications.

Conclusion

The public health emergency information system constructed in this study can be applied to public health departments such as disease prevention and control centres. Promotion can improve the efficiency of handling infectious disease outbreaks and provide a scientific basis for decision-making analysis.

Clinical characteristics and management strategies in adult foreign-body airway obstruction: A retrospective cohort study

by Hongzhen Yin, Tong Wang, Changshun Zhong, Yingya Cao, Xiaogan Jiang, Qiancheng Xu, Weihua Lu

Airway foreign-body aspiration in adults is uncommon but can be life-threatening.Flexible bronchoscopy is the standard first-line therapy,but critically ill patients may need extracorporeal life support.This study aims to characterize the diagnosis,management,and outcomes of adult airway foreign-body cases treated at a single center over nearly 12 years to inform a standardized clinical pathway.A single-center retrospective observational study of consecutive patients aged ≥14 years with confirmed airway foreign body who were treated at a tertiary hospital in China were conducted.Medical records of consecutive adolescent and adult patients diagnosed with airway foreign-body aspiration and admitted to the hospital from 01/01/ 2014–30/11/2025 were reviewed.Data included demographics,imaging,extraction method, respiratory support and so on.Descriptive statistics were reported as medians with interquartile ranges or counts and percentages.A total of 41 patients were included,with a median age of 59.5 years(interquartile ranges 51–72) and 65.85% male.Flexible bronchoscopy was attempted as the primary intervention in 38 patients(92.68%) and succeeded in 81.58%(31/38) to remove airway foreign body.Most patients(78.05%) required only nasal cannula oxygen,while nine patients(21.95%) needed advanced support including mechanical ventilation (14.63%),high-flow oxygen(4.88%),and extracorporeal life support (2.44%).At discharge,most survivors had a good neurological outcome,with 36 patients(87.80%) having a Cerebral Performance Categories score of 1.The 28-day survival rate was 92.68%.These findings show that flexible bronchoscopy is an effective first-line therapy,and rigid bronchoscopy or surgery is useful when flexible bronchoscopy fails.In unstable cases,timely extracorporeal life support can bridge to definitive removal.These results support a tiered,multidisciplinary approach incorporating early chest computed tomography,flexible bronchoscopy,and escalation to advanced airway or extracorporeal support.

Catheter body-surface fixation after transurethral prostate resection: A low-value nursing practice as evidenced in a randomized controlled trial

by Yanan Zhu, Qian Wang, Huiying Jia, Gaiyun Zhao, Yunpeng Lü, Xinhong Zhang, Haijing Dong

This randomized controlled trial is aimed at evaluating whether external fixation of the urinary catheter to the body surface represents a low-value nursing intervention for patients undergoing transurethral resection of the prostate (TURP). A total of 208 patients who received indwelling urinary catheters after TURP in a tertiary hospital in Qingdao, China between June 2024 and May 2025 were randomly assigned to one of two groups: a nonexternal fixation group (n = 103) and an external body surface fixation group (n = 105). A between-group comparison of outcomes included postoperative hematuria, incidence of catheter-associated urinary tract infection (CAUTI), unplanned catheter removal, occurrence of urinary catheter-related meatal pressure injury (UCR-MPI), and associated economic costs. No significant differences were observed between the two groups in terms of postoperative hematuria or CAUTI incidence (P > 0.05). Unplanned catheter removal did not occur in either group. However, UCR-MPI occurred significantly more frequently in the external fixation group (9 patients) than it did in the nonexternal fixation group (1 patient) (P 

Impacting Well‐Being and Resiliency of Pediatric Critical‐Care Nurses Through Implementation of MINDBODYSTRONG

ABSTRACT

Background

Growing numbers of clinicians are dealing with mental and behavioral health issues, including burnout, depression, and suicidal ideation. Prevalence of these conditions in pediatric critical-care (PCC) nurses is reported to be as high as 42%–77%.

Purpose

The purpose of this evidence-based quality improvement project was to implement a cognitive behavioral skills-building (CBSB) program to improve well-being and resiliency in PCC nurses.

Implementation Plan

The 7-week MINDBODYSTRONG (MBS) program was implemented with two cohorts of neonatal/PCC nurses in a 222-bed academic, tertiary care pediatric hospital, using a virtual platform and offering 1 sequential session per week. Each participant was asked to complete an anonymous baseline and post-program survey that included the following measures: Generalized Anxiety Disorder (GAD-2), Perceived Stress Scale (PSS4), Patient Health Questionnaire (PHQ-2), and a Single Item Measure of Burnout. Post-program surveys also included a MBS program evaluation.

Outcomes

Fifteen RNs registered for and completed the MBS program. 93.3% completed both the baseline and post-program survey. Results demonstrated positive clinical effects across all four mental health measures with large effects noted in the GAD-2 and PSS-4, and small effects noted in the PHQ-2 and the Single Item Measure of Burnout. 100% of participants found MBS helpful and recommended that it be offered to a wider audience.

Linking Evidence to Action

Implementation of the MBS CBSB program demonstrated clinical effectiveness on measures of anxiety, perceived stress, depression, and burnout in PCC nurses. The program was well received by participants. Strategies for broader implementation should be explored.

Association between self-reported poor sleep status and ovulation rate in Chinese women with fertility intentions: a multicentre prospective cohort study protocol

Por: Su · N.-j. · Huang · J. · Li · H. · Chen · H. · Wang · L. · Wang · S. · Huang · K. · Wang · J. · Huang · J. · Liao · Y. · Li · L. · Xiong · Z. · Ren · H. · Liu · B. · Chen · D. · Ma · N. · Yin · L. · Huang · C. · Zhang · X. · Liu · F.
Introduction

In China, women of childbearing age, who constitute a major demographic of online consumers and professionals in emerging industries are increasingly experiencing significant sleep disturbances. Existing studies have predominantly focused on the association between sleep disorders and polycystic ovary syndrome, often overlooking the independent impact of sleep patterns on ovulatory function in the general population of women attempting conception. Specifically, the synergistic effect of blue light exposure from electronic devices and delayed sleep onset remains underexplored, and evidence regarding the relationship between sleep duration, sleep quality and ovulation rates is insufficient. The primary objective of this study is to investigate the association between sleep habits and ovulation rates among Chinese women with fertility intentions. Second, it aims to determine the correlation between these sleep habits and factors such as screen time, night shift work and regional differences. Third, using a user-friendly sleep monitoring wristband, the study seeks to clarify the quantitative relationship between objective sleep parameters (eg, sleep onset time, sleep efficiency) and ovulation rates in this population.

Methods and analysis

This is a 1.5-year multicentre prospective cohort study. Participants will be recruited from at least five reproductive medicine centres in mainland China between May 2025 and December 2026. The study will enrol women aged 20–50 years with fertility intentions. Baseline demographic information and habitual sleep patterns will be assessed through standardised questionnaires, with participants self-reporting their sleep conditions. Prepregnancy biochemical indicators and anthropometric data will be recorded. The primary outcome will be the ovulation rate, with secondary outcomes including pregnancy rate and miscarriage rate.

Ethics and dissemination

This research project has been approved by the Clinical Research Ethics Committee of Guangdong Provincial Maternal and Child Health Hospital (Approval No.20250072), and has also received approval from the Primary and Specialty Nursing Committee for implementation and development. All participants will be informed verbally and in writing about the study procedures and objectives prior to signing the consent form. Data confidentiality will be ensured, and participants may withdraw their consent at any stage of the research. The findings will be presented at international conferences and published in peer-reviewed scientific journals.

Study of remimazolam besylate for general anaesthesia and population pharmacokinetics-pharmacodynamics in elderly, hepatic or renal-insufficient patients: a protocol for a multicentre randomised controlled trial in China

Por: Tang · M. · Zhu · M. · Chen · G. · Zhu · T. · Yin · Q.
Background

Remimazolam, an ultra-short-acting benzodiazepine, is characterised by rapid onset and recovery, metabolism independent of hepatic or renal function and haemostability. Despite the above pharmacokinetic (PK) advantages and potential benefits for renal- or hepatic-insufficient patients and the elderly patients, the effects and population pharmacokinetics–pharmacodynamics (popPK/PD) of remimazolam for general anaesthesia in elderly, hepatic or renal insufficient patients from large, randomised controlled trials remain unknown.

Methods and analysis

This is a randomised controlled single-blind multicentre study. Patients undergoing selective surgeries (eg, abdominal, orthopaedic or urologic procedures) will be screened and randomised into the elderly (age ≥65 years), hepatic insufficiency (Child-Pugh class B or C) or renal insufficiency (estimated glomerular filtration rate

Ethics and dissemination

This study was approved by the Ethics Committee of West China Hospital, Sichuan University, on 30 August 2024, and registered at the Chinese Clinical Trial Registry. The findings of this study will be disseminated through presentations at relevant conferences and published in peer-reviewed journals.

Trial registration number

ChiCTR2400089033.

Effectiveness of Nurse‐Led Interventions in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta‐Analysis

ABSTRACT

Background

The rising prevalence of cognitive impairment has made it a critical public health priority. Nurses are central to chronic disease management, yet the efficacy of the interventions in older adults with cognitive disorders remains uncertain.

Objective

To evaluate the efficacy of nurse-led interventions in older adults with cognitive disorders.

Methods

A comprehensive search was conducted across seven electronic databases from their inception to August 2025. This meta-analysis focused on nurse-led interventions. The primary outcome was cognitive function, and secondary outcomes included depressive symptoms and quality of life. Due to the heterogeneity of the studies, we employed a random effects model for the meta-analysis.

Results

The results indicated that nurse-led interventions significantly improved cognition (SMD = 0.64; 95% CI, 0.39–0.88; p < 0.05), substantially alleviated depressive symptoms (SMD = −0.32; 95% CI, −0.53–0.11; p < 0.05) and enhanced quality of life (QoL) (SMD = 0.40; 95% CI, 0.17–0.64; p < 0.05).

Conclusions

The results of this study indicate that nurse-led interventions are highly beneficial for elderly individuals with mild cognitive impairment (MCI) or dementia. In future research, it is necessary to comprehensively consider the roles that nurses undertake. They should play an active role in the recovery from chronic diseases. These findings provide an important basis for policymakers and clinicians.

Trial Registration

PROSPERO Registration number: CRD42024619016

Effects of deconstructed Tai Chi step training combined with conventional rehabilitation on lower limb function in brunnstrom stage III stroke patients: A randomized controlled trial

by Jinxin Chang, Pengcheng Qu, Yindong Li

Objective

To evaluate whether a deconstructed Tai Chi stepping protocol adapted for patients with Brunnstrom Stage III stroke, when combined with conventional rehabilitation, improves lower limb motor function, walking ability, and joint mobility compared with conventional rehabilitation plus limb synergy training.

Methods

In this assessor-blinded randomized controlled trial, 52 patients with subacute stroke (Brunnstrom Stage III, ≤ 6 months post-stroke) were randomized in a 1:1 ratio to an experimental group (conventional rehabilitation plus adapted Tai Chi stepping training) or a control group (conventional rehabilitation plus limb synergy training). Both interventions were delivered 5 days per week for 8 weeks. Fifty participants completed the study and were included in the final per-protocol analysis (25 per group). Outcomes were assessed at baseline and after intervention. The primary outcomes were the Fugl-Meyer Assessment for Lower Extremity (FMA-LE) and Holden Walking Function Classification. Secondary outcomes were hip, knee, and ankle range of motion (ROM).

Results

Both groups improved after treatment, with greater improvement observed in the experimental group. FMA-LE scores increased by 5.6 ± 1.5 points in the experimental group and 1.8 ± 0.8 points in the control group (p  Conclusion

Deconstructed Tai Chi stepping training combined with conventional rehabilitation was associated with greater improvement in lower limb motor function, walking ability, and joint mobility than conventional rehabilitation plus limb synergy training in patients with Brunnstrom Stage III stroke. This stage-specific protocol may represent a practical adjunct to stroke rehabilitation, although confirmation in larger trials is still needed.

Clinical trial registration

International Traditional Medicine Clinical Trial Registry (ITMCTR; a WHO ICTRP Primary Registry), registration number ITMCTR2025000972.

Gender Differences in Cardiac Rehabilitation Information Needs, Barriers and Participation Decisions Among Patients With Coronary Heart Disease: Fairlie Decomposition Analysis

ABSTRACT

Aim

Cardiac rehabilitation (CR) is an effective intervention for improving outcomes in patients with coronary heart disease (CHD). However, the actual participation rate is unsatisfactory and exhibits significant gender disparities. This study aimed to investigate gender-specific determinants of the decision to participate in CR among patients with CHD, together with underlying causes.

Design

Cross-sectional study.

Methods

A cross-sectional survey of 264 patients with CHD from 3 Chinese tertiary hospitals between February 2024 and February 2025. Data were collected using questionnaires based on the Information Need in Cardiac Rehabilitation scale, the Chinese version of Cardiac Rehabilitation Barriers Scale, the Family APGAR index questionnaire, and the International Physical Activity Questionnaire-Short Form.

Results

There were 158 men aged 66 (SD = 13.3) and 106 women aged 66 (SD = 11.0). 55.1% of men CHD patients decided to participate in CR, significantly higher than in women patients (34.0%; χ 2 = 11.351, p = 0.001). Logistic regression analysis for men indicated that the facilitators of the decision to participate in CR were the level of family functioning and ≥ 2 comorbidities. The barriers included emergency/safety information needs and functional status. For women, the facilitators were retirement, family functioning level, being overweight/obesity, ≥ 2 comorbidities, and work/vocational/social factors. The barriers included medication information needs, logistical factors, and functional status. Fairlie decomposition revealed gender differences primarily driven by work/vocational/social factors (contribution: 71.19%), functional status (50.50%), and retirement (−39.16%) (all p < 0.05).

Impact

This study highlights the necessity of gender-specific interventions during the decision-making phase for CR. Healthcare professionals should tailor CR strategies to address women's social role barriers and men's emergency risk concerns, while enhancing family functioning and targeting support for functional status and work-related factors.

Reporting Method

STROBE checklist, cross-sectional.

Patient or Public Contribution

Three tertiary hospitals assisted in participant recruitment.

Summary of Best Evidence for Noise Management in Neonatal Wards

ABSTRACT

Aim

This study aimed to retrieve, evaluate, and synthesize the best available evidence on noise management in neonatal wards to establish a foundational basis for implementing effective noise control practices.

Methods

Guided by the “6S” evidence pyramid model, a systematic search was performed across multiple sources including clinical decision support systems, guideline repositories, professional websites, and major databases up to April 12, 2025. Literature types encompassed guidelines, evidence summaries, expert consensuses, and systematic reviews. Following quality appraisal, two researchers independently extracted and synthesized the evidence.

Results

Sixteen publications were included: one guideline, six evidence summaries, six systematic reviews, and three expert consensuses. From these, 33 pieces of best evidence were synthesized and categorized into five key domains: noise sources, measurement techniques, threshold levels, reduction interventions, and clinical effects of noise.

Conclusions

This work provides a scientifically rigorous and comprehensive evidence summary for neonatal ward noise management, offering valuable guidance for clinical practice. Successful application requires adaptation to local contexts. Developing tailored, evidence-based implementation plans is recommended to bridge the evidence-practice gap and enhance neonatal outcomes.

Implications for Clinical Practice

Given neonates' heightened vulnerability, standardized noise management in the NICU is crucial. This summary provides clinicians with a robust, evidence-based framework to develop localized protocols. Its implementation is expected to improve the acoustic environment, thereby promoting physiological stability, supporting neurodevelopment, and reducing noise-related complications.

Reporting Method

This evidence summary followed the reporting specifications of the Fudan University Center for Evidence-Based Nursing (Joanna Briggs Institute methodology) and was registered (ES20257726).

Patient or Public Contribution

No Patient or Public Contribution.

Machine learning identifies pupil size and corneal thickness as key predictors of axial elongation rate

by Peng Zhou, Sitong Chen, Yingli Li, Yan Li

Purpose

This study aimed to develop a machine learning-based prediction model for myopia progression using ocular biometric parameters to provide an objective assessment tool for clinical practice.

Methods

A retrospective analysis was conducted on patients treated at Shanghai Parkway Health Ophthalmology Department as the training set, and myopic individuals from the Optometry Center of Peking University People’s Hospital as the validation set. Demographic and biometric data were collected, including central corneal thickness (CCT), axial length (AL), corneal curvature (K-value), anterior chamber depth (ACD), corneal diameter (WTW), and pupil size (PS). Seven machine learning models (e.g., XGBoost, random forest, support vector machine) were employed for modeling, with performance optimized via 5-fold cross-validation. Model accuracy was evaluated using mean squared error (MSE) and the coefficient of determination (R²), and variable importance was analyzed.

Results

No statistically significant differences were observed in baseline characteristics between the training and validation sets (all P > 0.05). The XGBoost model demonstrated the best performance, achieving R² = 0.913 (MSE = 0.005) on the training set and R² = 0.766 (MSE = 0.016) on the test set. Variable importance analysis revealed pupil size (score 100) and corneal thickness (40.88) as the key predictors of axial elongation rate, followed by age of onset (17.96).

Conclusion

The machine learning-based prediction model effectively utilizes ocular biometric data to assess myopia progression risk, with pupil size and corneal thickness identified as core predictive factors. This model provides a quantitative tool for early clinical intervention. Future studies should expand the sample size and incorporate additional biomarkers to optimize performance.

Insecticidal and knockdown resistance status of <i>Anopheles gambiae</i> s.l (Diptera: Culicidae) to pyrethroid and organophosphate insecticides in Osun State, Nigeria

by Lateef Oluwatoyin Busari, Zarat Oyindamola Iwalewa, Olabanji Ahmed Surakat, Adedapo Olufemi Adeogun, Akinlabi Mohammad Rufai, Kamilu Ayo Fasasi, Monsuru Adebayo Adeleke

Insecticide resistance in malaria vectors remains a global public health problem; however, little is known about resistance levels in Osun State, despite relatively high rates of malaria and distribution of insecticide-treated nets in the area. This study evaluates the resistance status of adult female Anopheles gambiae s.l to pyrethroids (permethrin, deltamethrin and alpha-cypermethrin) and an organophosphate (pirimiphos-methyl) insecticides and knockdown resistant (KDR) gene detection in six locations (Ido-Osun, Ipetumodu, Inisa, Ejigbo, Ijebu-Jesha and Ila) across the three senatorial districts in Osun State, Nigeria. Larval sampling was done between 0700hr and 1100hrs weekly between January and December 2022. Collected larvae were reared to the adult stage in the Department of Animal and Environmental Biology laboratory of Osun State University, Osogbo, Nigeria and then identified morphologically using morphological keys. Insecticide bioassay was conducted with permethrin (0.75%), deltamethrin (0.05%), alpha-cypermethrin (0.05%) and pirimiphos-methyl (0.25%) using WHO procedure. The mosquitoes were subjected to molecular analysis to detect the KDR gene. Pirimiphos-methyl showed significantly higher knockdown at 60 minutes (KD60) and achieved 100% mortality compared with the pyrethroids tested (p Anopheles gambiae s.l as compared to pyrethroids. Therefore, there is a need to intensify insecticide resistance surveillance of Anopheles in Osun State to plan indoor residual spraying with pirimiphos-methyl and explore the use of PBO or dual active ingredient insecticides treated nets (ITNs) to address the potential impacts of pyrethroid resistance.

Development and Psychometric Validation of the Palliative Care Experience Scale (PCES): An Experience‐Oriented Assessment Instrument

ABSTRACT

Aims

Accelerated population aging has driven substantial growth in demand for palliative care services. Such services can effectively enhance the living quality for end-of-life patients through multidimensional interventions. Currently, China lacks a localised experience-oriented quality assessment scale for palliative care, resulting in gaps in service quality supervision. To develop a self-reported measurement for palliative care services, with the foundation in the Senses Framework.

Design

This study developed a scale by extracting core contributors of palliative care experiences through 14 patients and 16 families' narratives. To refine and improve the scale, a total of 19 experts were invited to participate in a two-round Delphi expert consultation. Additionally, an empirical research was conducted, with 380 valid samples from two independent cohorts collected to complete the full psychometric testing of the scale.

Results

The final Palliative Care Experience Scale (PCES) comprises two dimensions: sense of security and belonging, and sense of purpose and significance, with a total of 13 items. The total variance includes 79.26% that is explained by these two factors. Confirmatory factor analysis confirmed a stable factor structure for the PCES. The scale exhibited good reliability, with a total Cronbach' α of 0.937, McDonald' ω of 0.952, and Spearman-Brown corrected split-half reliability of 0.897. Cronbach's α for both dimensions exceeded 0.88. The scale's SEM was 1.50 and MDC95 was 4.16, offering a validated threshold to identify real changes in patients' palliative care experience.

Conclusion

This study developed an assessment scale of palliative care quality based on the Senses Framework, uniquely centred on patient experiences. Validated through robust methodologies, this scale fills a gap in the evaluation of experiential dimensions of palliative care in China, providing a scientific and feasible measurement tool for the continuous improvement of services.

Impact

This study addresses the critical gap of a culturally adapted, patient experience-centred tool for evaluating palliative care service quality in China. Its core finding is the successful development and full psychometric validation of the 13-item Palliative Care Experience Scale (PCES). This research provides a reliable tool for palliative care clinical practice and academic research to capture patients' care experience, offers clinicians and administrators a practical instrument to identify service gaps and guide quality improvement, and delivers foundational reference data for policymakers to advance patient-centred palliative care development in China.

Reporting Method

We adhered to the relevant EQUATOR reporting guidelines. The development and validation process followed the COSMIN framework for patient-reported outcome measures.

Patient or Public Contribution

Patients receiving palliative care and familes played an integral role in designing and conducting this study. In Phase I, qualitative data from semi-structured interviews with 14 patients and 16 families helped define core thematic constructs and develop the initial item pool, which ensured the scale's content validity were based on their real-life experiences. In Phase III, we recruited a new, independent cohort of participants to complete the psychometric testing of the scale, providing key data for its validation.

Soluble ST2 as a biomarker for predicting severe adverse events among pediatric patients with Mycoplasma pneumoniae pneumonia

by Fangying Cheng, Tingting Li, Lei Zhang, Menghua Xu, Luxi Chen, Zhicheng Ye, Jin Xu

Aim

Mycoplasma pneumoniae (MP) is a leading cause of pneumonia in children. Early identification of patients at high risk is critical for improving outcomes. This study aimed to evaluate the association of soluble ST2 (sST2) with in-hospital adverse events in pediatric MP pneumonia (MPP).

Methods

We retrospectively analyzed 147 children with MPP admitted to the Children’s Hospital of Fudan University, Shanghai, China, between 01/04/2023 and 31/05/2024. Demographic, clinical, and laboratory data were collected, including sST2, inflammatory markers (CRP, PCT, IL-6), and blood cell counts. Severe adverse events were defined as in-hospital death, ICU admission, diagnosis of sepsis or use of extracorporeal membrane oxygenation.

Results

Twelve patients experienced severe adverse events and had significantly higher sST2 levels. ROC analysis showed that sST2 predicted severe adverse events (AUC = 0.944, 95% CI 0.894–0.975, P 

Sucralose inhibited cell survival through the activation of ER stress in human endothelial progenitor cells

by Chia-Ying Li, Hung-Yu Lin, En-Pei Isabel Chiang, Hung-Chang Hung, Feng-Yao Tang

Sucralose, a widely utilized non-caloric sweetener, is frequently added to food and beverage products as a sugar substitute aimed at lowering energy consumption and reducing obesity-related health risks. However, epidemiological studies have indicated a possible association between high intake of sucralose and increased prevalence of coronary artery disease (CAD). Prior research has demonstrated that diminished levels of circulating human endothelial progenitor cells (hEPCs) are linked to a higher risk of CAD. Although sucralose is broadly consumed, its direct biological impact on hEPCs has not been comprehensively characterized. In this study, we investigated the cellular effects of sucralose on hEPCs using a variety of in vitro techniques, including assays for viability, migration, capillary-like tube formation, lactate dehydrogenase (LDH) release-cytotoxicity assay, and protein expression profiling by Western blotting. Our results revealed that increased concentrations of sucralose significantly impaired hEPCs viability, motility, and neovasculogenic function, accompanied by increased expression of markers associated with apoptosis, inflammasome activation, and pyroptosis. Mechanistic analysis further demonstrated that sucralose strongly activated endoplasmic reticulum (ER) stress/PERK pathways in these cells. Inhibition of ER stress via 4-phenylbutyric acid (4-PBA) substantially attenuated sucralose-induced cell death and reduced the expression of pyroptosis-related proteins and inflammasome markers. Taken together, these findings suggest that sucralose disrupts hEPCs function in part by triggering ER stress, which promotes both apoptotic and pyroptotic cell death programs.

Beyond Autonomy? Understanding Patient Participation in Contemporary Nursing Care: A Focused Ethnography of Chronic Illness Contexts

ABSTRACT

Aim

To explore how chronically ill patients, family members and nurses perceive and experience patient participation in nursing care within a Chinese hospital context.

Design

Focused ethnography.

Methods

The study was conducted in a Chinese public hospital over 8 months between February and September 2021. Data were generated through 90 h of participant observation and 30 semi-structured interviews, including individual and dyadic interviews with 10 nurses, 17 patients and 7 family members. Data were analysed using reflexive thematic analysis through an inductive and iterative process.

Results

An overarching theme ‘participation as relational, holistic and dynamic’ was developed, comprising three themes: (1) participation as fulfilling individual responsibility, (2) family members as co-participants and (3) participation as an evolving multidimensional practice. These themes suggest that participation was understood as a relational responsibility enacted through everyday interactions. Family members were actively involved in care processes, and participation extended across physical, intellectual and emotional dimensions. Digital information and technologies further reshaped participation, creating new opportunities and tensions in everyday care.

Conclusion

Patient participation in nursing care extends beyond autonomy-based models and is shaped by relational responsibilities, family involvement and evolving digital healthcare contexts.

Implications for the Profession and/or Patient Care

To promote patient participation, policies and practices should recognise relational and family-based dimensions of care. Healthcare organisations should foster environments that support collaborative participation among patients, families and nurses. Training and education should be developed to promote nurses' digital literacy, cultural competence, ethical sensitivity and relational communication to support participation in contemporary care contexts.

Impact

This study broadens prevailing autonomy-centred understandings of patient participation by demonstrating how participation is co-constructed through relational responsibilities and family involvement. The findings offer insights for nursing practice and policy in culturally diverse and increasingly digital healthcare environments.

Reporting Methods

COREQ.

Patient or Public Contribution

No Patient or Public Contribution.

Exploring the Experiences of Community‐Dwelling Older Adults Participating in Group Interaction Programs: A Qualitative Meta‐Synthesis

ABSTRACT

Aim

To synthesise evidence from qualitative studies on community-dwelling older adults' experiences of social interactions in group interaction programmes.

Design

A systematic review and meta-synthesis based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines.

Methods

Two independent researchers screened the titles and abstracts of all retrieved studies based on eligibility criteria. Quality appraisal was conducted based on the comprehensive Critical Appraisal Skills Programme checklist. Data were extracted through an adapted Data Extraction Tool from the Joanna Briggs Institute Qualitative Assessment and Instrument. Findings were synthesised through the JBI meta-aggregation approach.

Data Sources

A literature search for peer-reviewed studies was conducted across seven databases from inception to September 2023.

Results

Our review included the experiences of 395 community-dwelling older adults across 25 studies, yielding the overarching theme of ‘Navigating relationships and facilitating growth in a supportive community’. Five themes were identified: feeling safe in a familiar environment, bringing people together, establishing meaningful relationships, improving personal well-being and facing socialising challenges.

Conclusion

Our findings provided not just theoretical insights but also practical implications. They can serve as a solid foundation for formulating or enhancing similar programmes, directly addressing the pervasive issues of loneliness and social isolation among the ageing population worldwide.

Implications for Nursing

This review improves our understanding of the social, emotional and personal benefits for older adults upon engaging in group interaction programmes. The insights into the elements of successful group interaction programmes for older adults, include providing a safe and familiar setting and bringing people together for socialisation. Future interventions should incorporate these elements to promote social interactions and community engagement more effectively to mitigate loneliness among older adults. Finally, the diverse range of programmes explored in this review demonstrates that future programmes can be flexibly formulated to suit different interests.

Patient and Public Contribution

The authors have nothing to report.

Protocol Registration

The review protocol has been registered on PROSPERO.

Perspectives and Requirements of Patients with Prostate Cancer on Mobile Health Interventions During Androgen Deprivation Therapy: A Descriptive Qualitative Study

ABSTRACT

Aim

To explore the perceptions of patients with prostate cancer undergoing androgen deprivation therapy towards mobile health interventions.

Design

The study employed a qualitative descriptive design.

Methods

Seventeen participants were recruited from tertiary care hospitals from November 2022 to June 2023. The collected data were subsequently analysed using a content analysis approach.

Results

The main themes were facilitators, barriers, information needs, emotional and social needs, and self-management needs. Facilitators for using mobile health included support from healthcare professionals and family, competitive design features and user-friendly interfaces. Barriers included negative past experiences with technology and a satisfactory current state of health. Informational support included those patients who expressed a desire for timely, accurate information integrated with traditional Chinese medical principles. Regarding emotional support, patients emphasised their independence, preferring not to burden family and friends, showing disinterest in mindfulness and relaxation therapies, and generally disliking online interactions with fellow patients. For self-management, medication reminders and rehabilitation guidance were seen as vital tools to enhance supportive care.

Conclusion

The study highlights the importance of customising mobile healthcare applications to meet unique needs among patients with prostate cancer and enhance their engagement and satisfaction. Understanding their specific preferences enables the development of more effective mobile healthcare applications.

Reporting Method

The COREQ checklist.

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