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This study aimed to examine the level of vicarious posttraumatic growth among intensive care unit nurses in China and explore the mediating role of death coping ability in the relationship between moral resilience and vicarious posttraumatic growth.
A multicentre, cross-sectional study was conducted in accordance with the STROBE guidelines.
Between January and March 2025, a questionnaire survey was conducted among 666 intensive care unit nurses from nine tertiary Grade A hospitals across five provinces in China. Participants completed three standardised instruments: the Rushton Moral Resilience Scale, the Coping with Death Scale–Short Version, and the Vicarious Posttraumatic Growth Inventory. We used IBM SPSS 27.0 for descriptive statistics, univariate analyses, and correlation analyses, and employed AMOS 27.0 to perform structural equation modelling for testing mediation effects.
Intensive care unit nurses demonstrated a moderate level of vicarious posttraumatic growth. Moral resilience was positively associated with both death coping ability and vicarious posttraumatic growth. Death coping ability was found to play a partial mediating role in the relationship between moral resilience and vicarious posttraumatic growth.
Moral resilience and death coping ability are key factors associated with vicarious posttraumatic growth among intensive care unit nurses. Nurses with stronger moral resilience are more likely to cope constructively with death-related stress, which may support psychological growth in trauma-intensive environments.
This study highlights the need to enhance intensive care unit nurses' moral and emotional capacities through ethics education, emotional coping training, and institutional support strategies. Strengthening these competencies may foster professional development and mental wellbeing in critical care settings.
Post-chronic pancreatitis (CP) diabetes mellitus (PPDM-C) is a distinct form of diabetes, in which complex pathogenesis hampers adequate glycaemic control. This study aimed to identify risk factors for poor glycaemic status in PPDM-C to guide clinical management.
Cross-sectional study.
Shanghai, China.
Between January 2018 and March 2023, 1677 patients with CP were enrolled in the CP database of the National Clinical Research Center. After application of strict exclusion criteria, 302 patients diagnosed with PPDM-C were included in the study.
The primary outcome was glycaemic control. The secondary outcomes were factors that affect glycaemic control among patients with PPDM-C.
This retrospective study was conducted in patients with PPDM-C. Poor glycaemic status was defined as a glycated haemoglobin A1c level of >7% at admission. Patients were stratified into those with and without diabetes treatment. Multivariate logistic regression was performed to identify risk factors. The area under the curve (AUC) analysis was used to evaluate the predictive efficacy of these risk factors.
A total of 302 patients with PPDM-C were analysed. Poor glycaemic status was observed in 72.6% (61/84) of patients without diabetes treatment and 52.8% (115/218) of those with diabetes treatment. For those without diabetes treatment, a history of acute pancreatitis (AP) attacks (OR: 4.838, p=0.014) and smoking (1–20 pack-years, OR: 4.418; >20 pack-years, OR: 9.989; p0.001). In patients with diabetes treatment, AP attack history (OR: 5.640, p20 pack-years, OR: 11.395; p
Patients with PPDM-C in China exhibited a high prevalence of poor glycaemic status. Smoking and a history of AP attacks were significantly associated with an increased risk of poor glycaemic control. The early identification of patients with PPDM-C at elevated risk of poor glycaemic control may facilitate timely and optimised management of glycaemia.
by Haoyang Zhou, Jinfeng Yang, Na Li, Jinying Li, Jianxin Ran, Yan Zheng, Yifan Long, Fang Cheng, Yuanpeng Liao
BackgroundSarcopenia is an age-associated disorder characterized by a progressive decline in skeletal muscle mass, strength, and physical function. The condition is linked to low levels of anabolic hormones such as insulin-like growth factor 1 (IGF-1), with its downstream phosphatidylinositol 3 kinase (PI3K)/ protein kinase B (AKT)/ forkhead box protein O3 (FOXO3) signaling pathway. There is growing evidence that resistance training (RT) or vibration training (VT) could improve physical functioning in individuals with sarcopenia. However, the related physiological influence of exercise on sarcopenia remains elusive.
MethodThis prospective randomized controlled trial will be conducted among 96 participants, aged between 65 and 80 years. In participants, sarcopenia diagnosis will be confirmed based on the Asian Working Group for Sarcopenia criteria, and participants will be randomized into either control, RT, VT, or RVT (combined RT and VT) groups. The intervention will last 12 weeks, with assessments performed at baseline, 12 weeks (after intervention), and 24 weeks (follow-up). The primary outcomes will include skeletal muscle mass, handgrip strength, and gait speed. Secondary outcomes comprise IGF-1 concentrations, PI3K/AKT and FOXO3 protein activity, quality of life, and timed-up-and-go test performance assessments.
DiscussionThis clinical study aims to elucidate the potential modulation of molecular mechanisms in vivo for combined RT and VT in sarcopenia patients and to identify the effects of the intervention on physical function.
Trial registrationChiCTR, ChiCTR2400083643. Registered on April 29, 2024.
Type 2 diabetes mellitus (T2DM) is a chronic non-communicable disease that requires long-term management to maintain blood glucose levels and prevent complications. Smart healthcare technologies have shown promising potential in enhancing self-management and treatment adherence among people with T2DM. However, current research on the use of smart healthcare in the continuum of care for T2DM showed considerable variation in intervention approaches, content and evaluation metrics, resulting in substantial heterogeneity across studies.
This scoping review aims to identify recurring intervention strategies, summarise commonly reported components and outline outcome indicators in the application of smart healthcare within the continuum of care for T2DM, to inform future research and practice by healthcare professionals.
This scoping review will follow the methodological framework proposed by Arksey and O’Malley. A comprehensive literature search will be conducted across PubMed (National Library of Medicine), Embase (Elsevier), Cumulative Index to Nursing and Allied Health Literature (CINAHL; EBSCO), Web of Science (Clarivate Analytics), the Cochrane Library (Wiley), Scopus (Elsevier), China National Knowledge Infrastructure (CNKI; China Academic Journals (CD-ROM) Electronic Publishing House), Wanfang Data (Beijing Wanfang Data Co., Ltd.), VIP Database (Chongqing VIP Information Co., Ltd.) and Chinese Biomedicine Literature Database (CBM; Chinese Academy of Medical Sciences). The search will include studies published from the inception of each database up to 25 April 2025. Two reviewers will independently screen the literature and extract data. Any disagreements will be resolved through discussion with a third reviewer. The review will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews.
Ethics approval is not required. Findings will be disseminated through professional networks, conference presentations and publication in a scientific journal.
The management of bleeding and coagulation after total knee arthroplasty (TKA) has long been recognised as a significant challenge for orthopaedic surgeons. Despite the notable success of empirical anticoagulation in preventing venous thromboembolism (VTE) following TKA, the increased risk of postoperative bleeding has also raised extensive concern. Ecchymosis, as one of the most common manifestations indicating postoperative bleeding, holds the potential to indicate the balance of bleeding and hypercoagulation. However, there is still a lack of evidence-based medical research to determine the importance of postoperative ecchymosis and related personalised anticoagulation therapy. Therefore, we have designed a randomised controlled trial aimed at assessing the safety and efficacy of personalised delayed anticoagulation strategies in the management of postoperative bleeding in TKA patients.
This is a prospective, randomised, controlled trial. Patients diagnosed with end-stage knee osteoarthritis will be grouped based on the presence of ecchymosis after TKA. Those without ecchymosis will receive standard anticoagulation therapy, while those with ecchymosis will be randomised in a 1:1 ratio into either the standard anticoagulation group or the delayed anticoagulation group. The primary outcomes will compare the blood routine examination, coagulogram, thromboelastography and the incidence of VTE. The secondary outcomes will include surgical-related complications. Additionally, patient baseline data and surgery-related data will also be recorded and analysed.
Ethics approval has been obtained from The First Affiliated Hospital of Chongqing Medical University (2024-194-01). The results will be disseminated at international conferences and in peer-reviewed publications.
ChiCTR2400084440.
Frailty is a common condition in older adults with diabetes, which significantly increases the risk of adverse health outcomes. Early identification of frailty in this population is crucial for implementing timely interventions. However, there is a lack of specific prediction models for frailty in older adults with diabetes. This study aims to develop and validate a prediction model for frailty in this high-risk group.
This study uses data from the national follow-up of the China Health and Retirement Longitudinal Study (CHARLS), which range from 2011 to 2020. The study population includes older adults with diabetes aged 60 and above. Frailty is assessed using Fried’s frailty phenotype. Potential predictors will be identified through a systematic review and expert consultation. Eight machine learning models will be developed to predict frailty, with model performance to be evaluated using receiver operating characteristic curves, calibration plots and internal validation through leave-one-out cross validation. Finally, the optimal model will be deployed via an electronic risk calculator with Shapley Additive Explanation-based visualisations.
The CHARLS was approved by the Biomedical Ethics Committee of Peking University (approval number: IRB00001052-11015), and all participants were required to sign informed consent. This study was approved by the Medical Research Ethics Committee of the University of South China (approval number: 2023NHHL006). We will disseminate results via presentations at scientific meetings and publication in peer-reviewed journals.
CRD42023470933.
This study aimed to assess the general population’s knowledge (K) of Parkinson’s disease symptoms and management, their attitudes (A) towards early detection and treatment, and their health-related practices (P) relevant to prevention and care.
A cross-sectional study.
This study was conducted between February and September 2023 at the Third Affiliated Hospital of Sun Yat-sen University, Yuedong Hospital.
This study was conducted among the general population.
Demographic information and KAP scores were collected through a self-administered questionnaire.
A total of 835 valid questionnaires were enrolled, including 445 (53.29%) men. The mean knowledge, attitudes and practices scores were 7.72±2.15 (possible range: 0–13), 30.75±2.74 (possible range: 9–45) and 45.22±5.31 (possible range: 13–65), respectively. Multivariate logistic regression analysis showed that knowledge score (OR=1.12, 95% CI 1.03 to 1.21, p=0.005), attitudes score (OR=1.10, 95% CI 1.03 to 1.18, p=0.002), being female (OR=3.34, 95% CI 2.39 to 4.66, p
The general population had inadequate knowledge, suboptimal attitudes and moderate practices towards Parkinson’s disease. It is recommended to implement targeted educational interventions to improve Parkinson’s disease knowledge, especially among those with lower educational attainment and income.
Thrombopoietin receptor agonists (TPO-RAs) are widely used in thrombocytopenia, yet their association with thromboembolic events (TEEs) remains concerning. This study aimed to assess the real-world TEE risk associated with TPO-RAs.
Retrospective pharmacovigilance analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) and Japanese Adverse Drug Event Report (JADER) databases.
Both FAERS and JADER were searched from January 2004 to March 2025.
Disproportionality analyses were performed using reporting OR (ROR), proportional reporting ratio (PRR), informational component (IC) and empirical Bayesian geometric mean (EBGM) to identify potential safety signals.
4005 TEE from FAERS and 569 from JADER were analysed. Venous TEE showed higher prevalence and signal intensity (FAERS: n=1489, ROR 4.19, PRR 4.14, EBGM05 3.94, IC025 0.37; JADER: n=269, ROR 15.95, PRR 14.27, EBGM05 12.56, IC025 2.14). Lusutrombopag had the strongest TEE signal (FAERS: n=7, ROR 8.80, PRR 7.77, EBGM05 4.00, IC025 1.25; JADER: n=41, ROR 38.02, PRR 16.94, EBGM05 11.45, IC025 2.38). FAERS identified 49 positive signals, while JADER identified 30, with 20 signals overlapping. Subgroup analysis indicated males had higher arterial TEE risk with TPO-RAs, while females had higher venous TEE risk in both FAERS and JADER. In FAERS, elderly (≥60 years) showed elevated arterial TEE risk with TPO-RAs and romiplostim, while non-elderly had higher venous TEE risk with avatrombopag and eltrombopag.
The study provided real-world evidence of TEE associated with TPO-RAs, highlighting a strong link despite variations in signal values and regional reporting practices. Findings underscore ongoing clinical safety surveillance for TPO-RAs.
Persistent diabetic macular edema (DME) with inadequate responsiveness to conventional inhibitors of vascular endothelial growth factor (VEGF) has caused significant vision loss and substantial treatment burdens. Brolucizumab is a new-generation anti-VEGF agent with better anatomical efficacy and prolonged duration of action. This single-centre, open-label, single-arm design clinical trial aims to evaluate the efficacy and safety of intravitreal brolucizumab 6 mg in Chinese subjects with persistent DME.
A total of 52 adult subjects with persistent DME will be recruited from Guangdong Provincial People’s Hospital. All study eyes will receive three consecutive 6 mg brolucizumab injections at intervals of 6 weeks. Disease activity assessment (DAA) will be arranged at week 18, and if disease activity is detected, subjects will continue with dosing of brolucizumab every 6 weeks (at weeks 18 and 24). Otherwise, the dosing will be adjusted to every 12 weeks (at week 24). The primary endpoints will be the proportion of patients with central subfield thickness (CST)
This study has been approved by the Ethics Review Committee of Guangdong Provincial People’s Hospital (KY2024-319). This study will be conducted in accordance with the ethical principles that have their origin in the Declaration of Helsinki and that are consistent with the ICH E6 guidelines for Good Clinical Practice and the applicable regulatory requirements. The study results will be submitted to a peer-reviewed journal and presented at both local and international congresses.
In China, there is a lack of standardised clinical imaging databases for multidimensional evaluation of cardiopulmonary diseases. To address this gap, this study protocol launched a project to build a clinical imaging technology integration and a multicentre database for early warning and stratification of cardiopulmonary dysfunction in the elderly.
This study employs a cross-sectional design, enrolling over 6000 elderly participants from five regions across China to evaluate cardiopulmonary function and related diseases. Based on clinical criteria, participants are categorized into three groups: a healthy cardiopulmonary function group, a functional decrease group and an established cardiopulmonary diseases group. All subjects will undergo comprehensive assessments including chest CT scans, echocardiography, and laboratory examinations. Additionally, at least 50 subjects will undergo cardiopulmonary exercise testing (CPET). By leveraging artificial intelligence technology, multimodal data will be integrated to establish reference ranges for cardiopulmonary function in the elderly population, as well as to develop early-warning models and severity grading standard models.
The study has been approved by the local ethics committee of Shanghai Changzheng Hospital (approval number: 2022SL069A). All the participants will sign the informed consent. The results will be disseminated through peer-reviewed publications and conferences.
Cerebral palsy (CP), the most common physical disability in children, imposes substantial economic and psychological burdens on families and society. The clinical management of CP remains challenging due to the limited efficacy of current treatments and the heterogeneity of its aetiologies and clinical presentations. This study aims to investigate the functional changes and identify influencing factors in Chinese children with CP. Through analysis of neuroimaging and genetic data, this study seeks to inform the development of preventive and therapeutic strategies and guide healthcare decision-making for this population.
This prospective cohort study aims to recruit 2051 children with CP across China. Baseline data will include demographic and clinical characteristics. Participants will undergo comprehensive assessments, including motor, cognitive, language, social, behavioural, nutritional, pain, sleep and quality-of-life domains, with regular follow-up evaluations. Trio whole-exome sequencing and detailed neuroimaging and musculoskeletal imaging will also be performed. This study will also assess caregivers’ quality of life and emotional burden. Mendelian randomisation will be adopted to evaluate genetic contributions to functional outcomes and their causal relationship with health metrics. Analytical methods will include correlation analysis, logistic regression (binary and multivariate), linear and non-linear mixed-effects models and structural equation modelling.
Ethics approval was granted by the Research Ethics Committee of Guangzhou Women and Children’s Medical Center (No.2023-346A01). All study procedures will adhere to the approved protocol. Study findings will be disseminated through peer-reviewed publications and conference presentations.
ChiCTR2300079017.
To develop and validate a risk prediction model for oral frailty in elderly patients with ischaemic stroke.
A cross-sectional study.
A temporal cohort of 633 elderly isachemic stroke patients from May 2024 to February 2025 was chronologically divided into a training set (n = 443) and validation set (n = 190). Participants were classified into oral frailty and non-oral frailty groups based on the Oral Frailty Index-8. In the training set, feature selection combined least absolute shrinkage and selection operator regression and random forest recursive feature elimination, followed by Nomogram Construction via Binary Logistic Regression. The model underwent internal validation using bootstrap resampling, and its generalizability was assessed with the validation set. The model was comprehensively evaluated using Receiver Operating Characteristic (ROC) curves, the Hosmer-Lemeshow Test, Calibration Plots, and Decision Curve Analysis (DCA).
In both the training and validation sets, the prevalence of oral frailty among elderly ischaemic stroke patients was 63.2% and 62.1%, respectively. Wearing dentures, tooth brushing frequency, dry mouth symptoms, chewing difficulty, swallowing function, oral health literacy, and oral health status were identified as significant predictors of oral frailty. ROC analysis demonstrated strong discriminative ability of the nomogram. The Hosmer-Lemeshow Test confirmed model consistency, and the calibration curve indicated excellent and stable calibration performance. DCA revealed that the model provided significant net clinical benefit in clinical practice. This free, interactive dynamic nomogram is accessible at: https://xiaowen.shinyapps.io/dynnomapp/.
This study presents a reliable, accessible model to assess oral frailty risk in elderly ischaemic stroke patients, facilitating clinical identification of high-risk individuals and providing a scientific foundation for oral health interventions.
The nomogram helps healthcare professionals identify high-risk patients, understand risk factors, and improve oral health management.
TRIPOD-AI checklist.
No patient or public contribution.
To translate and validate psychometric analyses across different cultures. Pressure injuries are a concern in healthcare. Negative attitudes hamper prevention efforts, yet Taiwan lacks a reliable assessment tool. Translate the Pressure Injury Prevention Attitude Scale, originally developed by Moore and Price, into the Taiwanese version, verify the psychometric analysis, and evaluate clinical nurses' attitudes toward pressure injury prevention. Brislin's forward and backward translation, along with verification processes, were employed to ensure that the translated Taiwanese version is culturally and linguistically appropriate for Taiwan. Content validity was evaluated by a panel of seven experts specializing in pressure injury. Confirmatory factor analysis affirmed the validity of both positive and negative measures within the attitude scale items. A sample of 330 nurses from a regional teaching hospital participated in assessing the instrument's construct validity, internal consistency, and test–retest reliability. Data collection occurred between April and May 2021. The Attitudes Toward Pressure Injury Prevention—Taiwanese Version exhibited robust psychometric properties, demonstrating high item-level content validity and internal consistency as indicated by Cronbach's α. Additionally, it showed impressive test–retest reliability. Confirmatory factor analysis identified two distinct factors, reflecting positive and negative attitudes. The Attitudes Toward Pressure Injury Prevention Scale–Taiwanese Version effectively assesses nurses' attitudes towards PI prevention in Taiwan. It also informs future research on the relationship between attitudes, knowledge and clinical performance. The Attitudes Toward Pressure Injury Prevention—Taiwanese Version serves as a valuable tool for assessing nurses' attitudes in Taiwan, enhancing preventive measures and patient care. Managers and educators can utilize attitude measures on pressure injury prevention to shape training strategies.
Obesity is a growing global public health problem that increases the risk of cardiovascular disease. The aim of the present study was to assess the effects of body composition on cardiometabolic indicators in children.
Cross-sectional analysis.
China, the Beijing Children and Adolescents Health Cohort Study between 2022 and 2023.
This cross-sectional study included 5555 children and adolescents aged 6 to 17 years from 11 kindergartens and schools.
We measured body composition using multifrequency bioelectrical impedance analysis and assessed the cardiometabolic indicators, including blood pressure, plasma glucose and lipids. Linear regression and binary logistic regression were performed to assess the associations between body composition and cardiometabolic abnormalities.
In boys, fat mass index (FMI) was positively correlated with total cholesterol (TC) (in normal fat-free mass (FFM) group, β=0.036, 95% CI 0.027 to 0.046; in high FFM group, β=0.034, 95% CI 0.016 to 0.051) and fasting plasma glucose (FPG) (in normal FFM group, β=0.019, 95% CI 0.012 to 0.026; in high FFM group, β=0.030, 95% CI 0.005 to 0.054). FFMI was negatively associated with TC only in the normal fat group (β=–0.047, 95% CI –0.069 to –0.034) in boys. However, in girls, FMI was not significantly associated with TC and was positively associated with FPG only in the normal FFM group (β=0.033, 95% CI 0.024 to 0.041), and FFMI was negatively correlated with TC (in normal fat group, β=–0.058, 95% CI –0.079 to –0.038; in high fat group, β=–0.049, 95% CI –0.084 to –0.015). Normal FFM-high fat (OR=2.065, 95% CI 1.379 to 3.091) and increased visceral fat region (OR=1.357, 95% CI 1.195 to 1.540) were risk factors for high TC in boys but not in girls.
Body composition was significantly associated with cardiometabolic risk factors, and fat stored in different regions has differential influences on cardiometabolic indicators. There were sex differences in the relationships between body composition and cardiometabolic indicators. The findings suggest that body composition is more strongly correlated with cardiometabolic indicators in boys than in girls. Prevention of obesity and cardiometabolic abnormalities may be more important in boys.
Several studies have indicated that transcutaneous electrical nerve stimulation, functional electrical stimulation, neuromuscular electrical stimulation and electroacupuncture exhibit certain therapeutic effects in the treatment of rheumatoid arthritis (RA). However, definitive proof of the effectiveness of different types of electrical stimulation in relieving the different symptomatic manifestations of RA is required. This study aims to analyse the efficacy (health assessment questionnaire, visual analogue scale, etc), safety (adverse reactions) of electrical stimulation for functional impairment (morning stiffness and decreased muscle strength) and pain (joint tenderness and swelling) of RA, and to explore their comparative advantages and potential benefits for patients.
We will conduct a systematic and comprehensive search of eight databases, and the search will proceed from the beginning to 5 September 2024. Two reviewers will independently screen the retrieved literature to determine the final included studies. Two reviewers will independently assess the risk of bias for all included eligible studies using the Cochrane Risk of Bias tool (V.2.0). Data synthesis will be performed using a random-effects model for network meta-analysis to compare the efficacy and safety of different electrical stimulations. The surface under the cumulative ranking curve will be used to demonstrate the probability of the benefits and harms of interventions. Funnel plots will be used to detect potential publication bias and small sample study effects. The strength of the evidence will be assessed through the Grading of Recommendations, Assessment, Development and Evaluation framework.
Our study data comes from public databases, and the entire study does not directly involve patients and the public, so ethical approval is not required. The final study results will be peer-reviewed and published in a journal.
CRD42024586835.
This study investigated alterations in the skin microclimate of the sacrococcygeal compression area in patients with malignant head and neck tumours before and after surgery. Additionally, it evaluated the effect of preventive dressings on the skin microclimate in this area and their association with intraoperative acquired pressure injuries (IAPIs), aiming to provide a foundation for preventing and reducing these injuries. Thirty patients were randomly assigned into control and two intervention groups. The sacrococcygeal skin of the control group was not protected by preventive dressing. Intervention group A was protected by silicone foam dressing, and intervention group B received a combination of liquid dressing and silicone foam dressing. Sacrococcygeal skin temperature, skin moisture levels and sebum were measured at admission, before and after surgery, and post-operative skin and pain were evaluated. There were no significant differences in skin temperature, moisture levels or sebum between the three groups before and after the intervention. The incidence of IAPI was significantly different (χ 2 = 6.240, p = 0.044). No significant difference was observed in post-operative pain incidence. Preventive dressings did not significantly alter the skin microclimate but reduced the risk of IAPIs.
To construct a nursing programme to manage intra-abdominal pressure (IAP) in neurocritical care patients.
The consensus of 16 experts was collected using a two-round Delphi method.
First, we developed the early stages of the nursing programme for managing IAP in neurocritical care patients through preliminary study and relevant literature internationally. A questionnaire was then distributed to a panel of 16 experts, each with over 10 years of experience in respiratory critical care, neurocritical care or comprehensive intensive care unit treatment. Between April and May 2024, these experts reviewed the preliminary programme and provided feedback and recommendations for modifications.
Two rounds of expert consultation were conducted. After the first round of expert feedback, 22 items were revised. In the second round, eight additional items were revised. The questionnaire recovery rates in both rounds of correspondence were 88.9% and 100%, and the authority coefficients were 0.869 and 0.888, respectively. The Kendall W values ranged from 0.127 to 0.336 (p < 0.001). Consensus was reached on six Level 1 entries, 17 Level 2 entries, and 50 Level 3 entries.
A panel of 16 experts approved the proposed nursing approach for managing IAP in neurocritical care.
This nursing protocol offers a systematic approach for managing IAP throughout all stages of care in neurocritical settings. Moreover, this programme can guide neurocritical care nurses in maintaining optimal IAP at critical times. The protocol could potentially be used in training nurses on IAP regulation and enhancing their management skills in this specialised area of care, along with preventing IAP-related health issues.
The study is reported in accordance with the Guidance on Conducting and Reporting DElphi Studies (CREDES) recommendations.
No patient or public contribution.
by Bin Li, Jinjin Wang, Jianlong Ge, Meijie Liao, Xiaojun Rong, Jinyan Wang, Yingeng Wang, Zheng Zhang, Chunyuan Wang, Yongxiang Yu
In order to study the optimal use of Lactobacillus plantarum in sea cucumber (Apostichopus japonicus), 49 days feeding trial was conducted to determine the influence of immersion bathing in different concentrations of Lactobacillus plantarum CLY-05 on body weight gain rate and non-specific immune activities. The potential effect of CLY-05 on gut microbiota was also analyzed during the immersion bathing at the optimum concentration. The results showed that the body weight growth rate of all bathing groups was higher than that of control. The highest specific growth rate (4.58%) and weight gain rate (25.35%) was achieved at the bacterial concentration of 1×103 CFU/mL. The activities of non-specific immune enzymes (ACP, AKP, SOD and LZM) of all bathing groups increased after immersion bathing, and the enzyme activities of groups bathed with the bacterium at 1×103 and 1×104 CFU/mL reached the highest. Therefore, 1×103 CFU/mL was considered as the optimum concentration of L. plantarum CLY-05 for A. japonicus pond culture. The results of gut microbiota analysis showed that the gut microbiota changed with the addition of L. plantarum CLY-05, and the richness and diversity of the gut microbiota peaked on day 14 and day 21, respectively. The correlation analysis revealed that the non-specific immune enzyme activities were significantly correlated to some gut bacteria (in the phyla Proteobacteria, Firmicutes) after immersion bathing in L. plantarum CLY-05. These findings provide the theoretical foundation for probiotic application in sea cucumber farming.To analyse risk factors for early neurological damage in young and middle-aged stroke cases.
Totally 405 young and middle-aged stroke patients in the neurocritical care unit (NCU) were selected and divided into the developmental (260 patients) and validation (145 patients) sets. The 405 cases were also grouped based on whether early neurological deterioration (END) occurred. The influencing factors of END were analysed by logistic regression, followed by the construction of a nomogram for predicting the risk of END. The Bootstrap method was applied to internally verify the predictive value of the model, using validation set data.
Age, type of stroke, diabetes, mechanical ventilation, pulse, initial National Institute of Health stroke scale (NIHSS), Barthel index (BI), haemoglobin, hypersensitive C-reactive protein (hs-CRP), triglyceride glucose (TyG) index and CONUT showed statistically significant differences (p < 0.05). Logistic regression analysis revealed type of stroke, initial NIHSS, CONUT, TyG index and hs-CRP were risk factors for END in young and middle-aged stroke cases (OR > 1, p < 0.05). The area under the curve (AUC) for the developmental set was 0.842, and internal validation results showed a C-index of 0.843; the AUC for the validation set was 0.843.
The nomogram constructed in this study has good predictive efficacy and can provide reference for early clinical prediction of END in young and middle-aged stroke cases.
The importance of this research lies in shedding light on the significant impact of early neurological deterioration on the health outcomes of young and middle-aged stroke patients, particularly in the short term. To guide clinical workers to identify risk factors early and improve the prognosis of stroke patients.
FreshRSS 