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Integrated digital diagnostics can support complex surgeries in many anatomic sites, and brain tumour surgery represents one of the most complex cases. Neurosurgeons face several challenges during brain tumour surgeries, such as differentiating critical tissue from brain tumour margins. To overcome these challenges, the STRATUM project will develop a 3D decision support tool for brain surgery guidance and diagnostics based on multimodal data processing, including hyperspectral imaging, integrated as a point-of-care computing tool in neurosurgical workflows. This paper reports the protocol for the development and technical validation of the STRATUM tool.
This international multicentre, prospective, open, observational cohort study, STRATUM-OS (study: 28 months, pre-recruitment: 2 months, recruitment: 20 months, follow-up: 6 months), with no control group, will collect data from 320 patients undergoing standard neurosurgical procedures to: (1) develop and technically validate the STRATUM tool and (2) collect the outcome measures for comparing the standard procedure versus the standard procedure plus the use of the STRATUM tool during surgery in a subsequent historically controlled non-randomised clinical trial.
The protocol was approved by the participant ethics committees. Results will be disseminated in scientific conferences and peer-reviewed journals.
Objetivo: analizar las ITU en una Residencia y diseñar una estrategia de manejo y prevención. Metodología: estudio descriptivo, retrospectivo y longitudinal de ancianos institucionalizados en una Residencia de Cádiz entre el 1/abril/2015 al 31/marzo/2016. Seleccionamos aquellos que padecieron al menos un episodio de ITU. No presentamos criterios de exclusión. Resultados: contamos con 119 residentes, (media de 88/mes), presentaron infección 44 (75% mujeres). Edad entre 71 y 102 años, moda y mediana de 84. Tasa de incidencia global 49%/año. Sondaje vesical un 15,90% e incontinencia urinaria 86,36%. El 79.1% fueron episodios agudos, 20.9% crónicos y el 68.08% recidivaron. Manifestaciones clínicas: fiebre, astenia, dolor, hiperglucemia y hematuria. Escherichia coli. como germen más habitual. Conclusión: constatamos alta prevalencia de ITU mejorable con estrategia de gestión multidisciplinar, evitando sobrediagnóstico y sobretratamiento y prevención primaria con probióticos.
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