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Music-based training programmes, such as learning how to play an instrument or sing in a choir, have been suggested as potential interventions for promoting healthy brain ageing in older adults at risk of cognitive decline because of their ability to enhance cognitive functions and potentially promote neuroplasticity. However, there is limited empirical evidence in older adults at risk of dementia, especially that evaluates both piano and singing interventions and their effects on cognition and neuroplasticity. In this protocol, we outline a study to assess the efficacy of keyboard and singing music training programmes on reducing cognitive decline and other outcomes in older adults with Mild Cognitive Impairment (MCI).
This randomised, single-blind, controlled, parallel-group trial aims to enrol 432 individuals with MCI from the community in Sydney, Australia. Participants are randomly allocated to participate in either keyboard lessons, singing lessons or a film discussion control group once a week for 3 months. The primary objective is to assess the effectiveness of two music training programmes (keyboard and choral singing) for enhancing verbal memory after 3 months compared with control. Additionally, we will examine how these music-based interventions affect other aspects of cognition, mood, sleep, overall well-being, markers of brain plasticity and blood biomarkers of Alzheimer’s disease and neurodegeneration. Tertiary objectives are to identify factors that impact the success of the interventions, such as participation rates, engagement levels and key demographic and clinical features. Outcomes are collected at baseline and at 3 and 9 months. The primary endpoint analysis will include all randomised participants to estimate the treatment effect using intention-to-treat principles. Primary and secondary outcomes will be analysed using linear mixed models and effect size measures will be calculated.
This study will be the first robust, randomised controlled trial to assess the potential and relative value of music engagement for cognitive decline in high-risk MCI individuals, as well as broader effects on other markers of mental health, well-being and neurodegeneration. Co-designed with implementation in mind, the music interventions can potentially be delivered within memory clinic or community settings.
The Sydney University Human Research Ethics Committee (2023-026) has approved this protocol. The trial findings will be shared through conferences, publications and media.
Australian and New Zealand Clinical Trials Registry (ACTRN12623000407695), Registered 21/04/2023 https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=385552
2.02 29/11/2024.
To analyse the impact of a participatory process of awareness and reflection on compassion, in the face of end-of-life processes, in students aged 12–23 years in six Spanish regions, and to understand how the participatory process can transform their compassion.
Mixed sequential transformative methodology with different phases. In the first phase, a prospective quasi-experimental design with evaluation pre-post in a single group will be adopted. The second phase is the intervention under study, which will consist of a Participatory Action Research with concurrent evaluations.
In the quantitative phase, 1390 students aged 12–23 from a Public University and a Public Secondary Education Institute across six different Spanish regions will be included. A single questionnaire will be administered before and after the Participatory Action Research to contribute to the process evaluation, incorporating four scales (compassion for others' lives, Death Anxiety Scale, basic empathy modified for adolescents and self-compassion). Responses will be recorded in the Research Electronic Data Capture system. For data analysis, comparison groups, change evolution and associations between variables will be examined, along with multivariate logistic regression models. In the qualitative phase of participatory action research, a promoter group will be established in each university and secondary school in every region. Qualitative data will be analysed following the authenticity, transferability, auditability and neutrality criteria. Discourse analysis triangulation will be conducted to achieve data saturation.
Implementing participative action research in the educational environment to improve students' compassion makes them capable of founding compassion communities to help those who have a terminal illness.
This study will adhere to the relevant EQUATOR guidelines, such as the Good Reporting of a Mixed Methods Study guideline, to efficiently report its results through the different steps of this mixed-methods study.
Participatory action research is a method that enables participants to act as researchers of the phenomenon under study, facilitating the immediate application of results within the context. Although students did not participate in the writing of the proposal grant or the research design.
This study registered on Clinical Trials (NCT06310434), was initiated in January 2024, and it will continue up to December 2026.
This multicentre study will contribute to the nursing community with an overview of compassion for those at the end of their lives among young people and provide the knowledge needed to cultivate compassion at universities and schools.
Implementing compassion programmes and death education in the educational environment will empower students to create a compassionate community. The double evaluation of the process will contribute to the qualitative databases.
Objetivo: Generar una teoría de situación específica para explicar el control de miedo, ansiedad y estrés postraumático en personal de enfermería que atendió a pacientes Covid. Desarrollo: La teoría de las transiciones, fue base para la teoría de situación específica con los cuatro pasos de Dulock y Holzemer: (1) identificar y aislar principales conceptos, (2) especificar relaciones entre conceptos, (3) ordenar jerárquicamente los conceptos según nivel de abstracción, y (4) ilustrar relaciones actuales entre variables. Conclusión principal: La teoría de situación específica para explicar el control de miedo, ansiedad y estrés postraumático basada en la Teoría de las Transiciones es útil para explicar las condiciones de transición personales que facilitan e inhiben el paso hacia un nuevo rol de cuidado y explicar indicadores que intervienen en el proceso y resultado en el personal de enfermería.
Objetivo principal: Determinar la efectividad de la hipotermia terapéutica (HT) como medida de neuroprotección y de reducción de la mortalidad en recién nacidos con encefalopatía hipóxico-isquémica (EHI). Metodología: Enfermería Basada en Evidencia. Bases de datos consultadas: Cinahl, Cuiden, Epistemonikos, Lilacs, PubMed, Scopus, Scient Direct, Scielo, Librería Cochrane y Google Académico, traducción documental a través del DeCS, lectura crítica realizada mediante FLC 3.0 y síntesis de la evidencia de acuerdo con la escala Oxford. Resultados principales: 18 estudios comparados, encontrándose un 83% de efectividad neuroprotectora de la HT, evidenciando la importancia de su aplicación en tiempos <6 y 6-12 horas. Conclusiones principales: La HT tiene un impacto positivo en el tratamiento de la EHI de moderada a grave, mejora la neuroprotección, aumenta la función neurológica y el pronóstico del sistema nervioso, disminuye la discapacidad grave y la tasa de morbimortalidad neonatal.
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