Non-occupational post-exposure prophylaxis (nPEP) and pre-exposure prophylaxis (PrEP) are effective HIV prevention methods, but their use is low in Sub-Saharan Africa (SSA). Mobile applications (apps) could increase uptake and adherence to these interventions, yet research on their use in communities is limited. Furthermore, there is limited information on the design and development of these apps, impacting their implementation. This scoping review aims to identify, analyse and evaluate mobile apps designed to improve nPEP uptake, adherence and linkage to PrEP services focusing on key features, barriers and facilitators. It also seeks to address gaps in studies assessing the feasibility, usability and acceptability of these apps, with the goal of informing future research, healthcare policies and public health strategies to reduce the HIV burden in Sub-Saharan Africa.

This review will follow the Arksey and O'Malley framework and search databases such as PubMed, Scopus and Web of Science for relevant studies. Two independent reviewers will screen and assess full-text studies. Primarily, the review will include studies on digital interventions for nPEP and PrEP, excluding opinion papers, narrative reviews and sub-studies. Grey literature from sources like Google Scholar will also be considered. Data will be captured using a charting form, and results will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews framework. Completion is expected in December 2025.

No ethical approval is required as publicly available materials will be used. Results will be shared through peer-reviewed journals, conferences and with policymakers to inform HIV prevention strategies.

Acute kidney injury (AKI) is a complex, devastating condition characterised by a sudden reduction in renal function, leading to increased mortality and healthcare costs globally. Outcomes of AKI are worsened by factors such as limited access to healthcare, delayed hospital presentation and underlying comorbidities, which severely affect patients in sub-Saharan Africa. The renal resistive index (RRI) has come into view as an encouraging non-invasive imaging approach for the early prediction of AKI. However, the use of the RRI for AKI prediction in sub-Saharan Africa is poorly documented. This research aims to map and describe the evidence for using the RRI for the early detection of AKI in sub-Saharan Africa.

The Joanna Briggs Institute methodology for scoping reviews will be used for this study. It will include a comprehensive search of electronic databases, grey literature (including academic proceedings), as well as an extensive literature review of relevant journals. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews will also be used as a guide. Discrepancies will be handled by consensus or by consulting a third reviewer. This evidence synthesis will explore the usefulness and accuracy of the RRI for early prediction of AKI in sub-Saharan Africa, where the patients are generally younger and have different AKI risk predictors and cardiovascular profiles compared with patients in high-income countries. Evidence of implementation and associated challenges will also be explored. These challenges may include limited access to specialised ultrasound equipment and a lack of trained healthcare providers proficient in RRI measurement and interpretation. The findings will inform future studies and be useful for healthcare providers, policymakers and patient advocates seeking sustainable strategies for preventing AKI.

Ethical approval is not required for this scoping review. The findings of this review will be published in a peer-reviewed journal and presented to decision-makers, health system administrators and healthcare providers at national and international academic conferences.