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Public Attitudes Towards Expanding the Role of Advanced Practice Nurses in Germany: A Cross‐Sectional Survey Study

ABSTRACT

Aim

To assess public support and predictors of favourable or unfavourable views towards expanding Advanced Practice Nurse (APN) roles in Germany.

Design

A quantitative, cross-sectional survey using Germany as a national case study.

Methods

Data came from the Politikpanel Deutschland, an online survey conducted 15–28 July 2024. After exclusions, 6733 respondents were included. Data were weighted by age, gender, federal state, and voting intention. Descriptive statistics, subgroup comparisons, and multinomial logistic regression were applied to analyse attitudes towards APNs, with results reported as average marginal effects and predicted probabilities.

Results

Overall, 52.8% of respondents supported expanding APN roles, 25% opposed, and the remainder were undecided. Support was stronger among younger, male, and highly educated respondents, and those open to digital health technologies. Support was lower in East Germany and the city-states Berlin and Bremen, while it was higher in the south-west and north. Political ideology strongly predicted attitudes: supporters of right-wing parties were more likely to oppose, whereas left-leaning voters were more supportive.

Conclusions

Public support for expanding APN roles in Germany is moderate but uneven across demographic, regional, and political cohorts. Younger individuals and those favouring digital health technologies may drive future acceptance, while political resistance and regional disparities remain barriers.

Impact

This first, large-scale survey of German public attitudes towards APNs suggests that policymakers should (i) link APN role expansion with digital health innovations, (ii) address regional differences through tailored communication, and (iii) ensure that patients, physicians, and healthcare professionals perceive APN integration as enhancing, not diminishing primary care quality. Strengthening legal and educational frameworks and fostering collaboration between physicians and nurses will not only be essential to integrate APNs into Germany's healthcare system and, thereby, mitigate physician shortages, but also to foster public acceptance of APNs.

Patient or Public Contribution

None.

Reporting Method

CROSS-checklist.

Improving the composition of donor milk using machine learning and optimisation techniques

by Jacqueline Muts, Danée Knevel, Dick den Hertog, Rachel K. Wong, Timothy C.Y. Chan, Britt J. van Keulen, Johannes B. van Goudoever, Chris H.P. van den Akker

Background and aims

The macronutrient composition of donor human milk (DHM) can vary substantially due to several factors such as maternal age, diet, and lactation duration. However, consistent macronutrient levels in DHM facilitate the administration of the required amounts to preterm infants. The current pooling strategy at most human milk banks combines milk from different batches from a single donor. This study aims to stabilize the macronutrient quality of DHM by pooling milk from different donors by utilizing machine learning prediction and optimisation techniques.

Methods

The current pooling strategy is compared with a new theoretical approach that pools milk batches from up to 5 donors. To predict the crude protein and energy content, we used the following variables: body mass index, the donor’s diet (vegetarian or non-vegetarian), maternal age, full-term or preterm delivery, lactation stage, and volume pumped. These predictions are then used within an optimisation model to create milk pools that minimize the deviations from the target macronutrient levels (1.0 g protein/100 mL and 70 kcal/100 mL).

Results

The prediction model is based on 2236 created single-donor pools from 480 donors. Random forest regression models provided the most accurate predictions of macronutrient content. The new pooling strategy using multiple donors shows reduced deviations from target values compared to the current single-donor approach (average total absolute deviation 0.402 versus 0.664).

Conclusion

This study proves the potential of data-driven methods to improve operational efficiency in human milk banks, and improving the consistency of donor human milk.

Supported implementation of tailored hospital fall prevention interventions: a protocol for the PROTECT stepped wedge type I hybrid effectiveness-implementation trial

Por: McLennan · C. · Hassett · L. · Tilden · W. · Naganathan · V. · Haynes · A. · Jennings · M. · Ni Chroinin · D. · Richards · B. · Hallahan · A. · Biswas · R. K. · Kwok · W. · McVeigh · T. · Heppleston · E. · Jackson · D. · Nayak · V. · Delaney · S. · Howard · K. · Pinheiro · M. · Macpherson
Introduction

Patient falls in hospitals lead to patient harm, staff distress and economic burden on health systems. There are few strategies with robust evidence demonstrating benefit for the prevention of falls, especially in acute hospital settings. Education and multicomponent fall prevention approaches are promising. Rigorous systematic measurement of implementation has been lacking in most hospital fall prevention trials. This paper describes the protocol for a trial that will evaluate the impact of supported implementation of tailored multicomponent fall prevention interventions on patient falls in hospital.

Methods and analysis

A stepped-wedge hybrid type I effectiveness implementation cluster randomised trial will be conducted. Twelve inpatient wards across four metropolitan hospitals will be enrolled in the trial, clustered into groups of four and randomised to commence the intervention at one of three time periods. Patients and ward staff will be recruited to complete pre-implementation surveys, which, combined with analysis of routinely collected local falls data and staff brainstorming, will inform tailored multicomponent fall prevention interventions for each ward. Wards will receive quality improvement training, clinical facilitation and staff education for at least 4 months to support implementation of their fall prevention interventions. The primary outcome—rate of falls—will be measured using routinely collected hospital falls data from the incident management system and medical records. Pre-implementation and post-implementation patient and staff surveys, qualitative interviews and bedside audits will measure secondary effectiveness and implementation outcomes. Healthcare utilisation from hospital data will inform the cost-effectiveness analysis.

Ethics and dissemination

The Sydney Local Health District Human Research Ethics Committee (RPAH Zone) approved this trial (protocol number X24-0087 and 2024/ETH00583). The trial is registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12624000896572). Data collection commenced in October 2024, due for completion in May 2026. Results will be published in reputable international journals and presented at relevant conferences.

Trial registration number

Australian and New Zealand Clinical Trials Registry (ACTRN12624000896572).

Pain Services in the Netherlands: A Cross‐Sectional Questionnaire Study on Organisation, Tasks and Responsibilities

ABSTRACT

Aims

Providing an overview of the organisation, tasks, and responsibilities of acute and transitional pain services in the Netherlands.

Design

Cross-sectional questionnaire study.

Methods

An online questionnaire was sent to representatives of Dutch hospital pain services performing inpatient surgery. It included items on organisation, staffing, education, roles, tasks and responsibilities. Data were analysed descriptively.

Results

Of the surveyed hospitals, 92.2% reported having an acute pain service, while only 6.5% had a transitional pain service. Most pain services (acute pain services 76.3%, transitional pain services 80.0%) are part of the anaesthesiology department. Staffing includes anaesthesiologists, nurses, and/or nurse anaesthetists, with or without pain specialisation. Acute pain service teams monitor complex pain management techniques. Nearly all acute pain services (89.8%) provide pain management training, and 60% monitor hospital-wide pain management quality. All transitional pain services monitored opioid use post-discharge and conducted follow-up calls with patients.

Conclusions

Acute pain services are well established in Dutch hospitals, whereas transitional pain services remain limited. Organisational structures, tasks, and responsibilities vary, with key challenges in staffing, service organisation, and education. Future research should focus on optimising staffing, expanding transitional pain services, the role of the pain nurse, and establishing a national pain management education framework.

Implications for the Profession and Patient Care

This study highlights the significant impact of pain nurses as a central professional within the interdisciplinary team, contributing to quality care and education, ultimately benefiting patients.

Impact

This study provides a current overview of pain services in the Netherlands, supporting pain nurses in innovating pain services, highlighting key challenges and opportunities for improvement.

Reporting Method

STROBE checklist.

Patient/Public Involvement

None.

Deployment of Perioperative Nurses From Their Clinical Specialty During the COVID‐19 Pandemic: An Integrative Review

ABSTRACT

Aim

To identify the available records surrounding the deployment of perioperative nurses into differing clinical settings during the COVID-19 pandemic.

Design

Integrative review methodology.

Methods

Quality appraisal of each record was conducted using a modified Critical Appraisal Skills Programme checklist. Data were extracted and presented based on outlined research objectives.

Data Sources

Six electronic databases (CINAHL Plus, Google Scholar, MEDLINE, Pubmed, Scopus, and Web of Science) were searched, with relevant peer-reviewed records published after 2019 until February 2025 included to differentiate from other respiratory pandemics.

Results

Ten records were included in the review. Opposing discourse exists between perioperative decision makers and those perioperative nurses who underwent deployment to differing clinical areas surrounding perceptions and experiences of deployment during the COVID-19 pandemic.

Conclusion

Few studies exist exploring experiences of perioperative nurse deployment to a different clinical area during the COVID-19 pandemic. Further research is vital to develop strategies that enhance the deployment process and ensure effective patient care across various clinical settings when cared for by deployed perioperative nurses.

Implications for the Profession and/or Patient Care

Further research exploring transferable perioperative nursing skills and its subsequent influence on safe patient care may enhance and inform nurse deployment practices, enriching future staffing protocols in the event of a future pandemic.

Reporting Method

PRISMA guidelines for reporting systematic reviews guided this review.

Patient or Public Contribution

This study did not include patient or public involvement in its design, conduct, or reporting.

Safe, Sustainable and Ethical Recruitment of Internationally Qualified Registered Nurses to Australia

ABSTRACT

Aim

To critically examine the safety, sustainability and ethical dimensions of recruiting internationally qualified nurses to Australia. A Global Justice Framework focusing on the political ethics of care is applied to the complexity and practical application of issues raised by the urgent nursing workforce needs in the health and aged care sectors.

Design

A discursive paper based on a critical reading of the literature.

Methods

Based broadly on a narrative review, this paper provides a critical analysis of relevant literature identified through CINAHL and PubMed databases. These included peer-reviewed articles, government reports, international guidelines and policy documents. Key issues identified included patient safety, sustainability and ethical considerations pertaining to international nurse migration.

Findings

Australia has rigorous standards for assessing the professional competency of Internationally Qualified Registered Nurses to ensure safety. Challenges persist, however, regarding professional integration, retention and adherence to ethical recruitment practices. While nurse migration alleviates workforce shortages in Australia, it exacerbates healthcare deficits in source countries facing critical shortages. Sustainability concerns include ensuring long-term workforce stability and maintaining high-quality care standards. Bilateral agreements must consider the needs of both source and host countries.

Conclusion

Addressing Australia's nursing workforce shortages requires ethical and sustainable recruitment strategies. Workforce demands must be balanced to ensure global health equity while upholding public safety and professional standards for all countries.

Implications for the Profession and/or Patient Care

Ethical recruitment practices are essential for developing policies and practices that support internationally qualified nurses' professional integration and retention. Establishing robust support systems enables these nurses to adapt effectively to Australian healthcare settings. Strengthening retention strategies fosters workforce stability, minimises attrition and may contribute towards consistent delivery of high-quality and safe patient care.

Culturally and Linguistically Diverse Informal Carer Experiences of Older Adult Care Transitions From Hospital to Home: A Scoping Review

ABSTRACT

Aim

To review the evidence on the experiences and perceptions of culturally and linguistically diverse informal carers supporting older adults during transitions from hospital to home, including their interactions with transitional care interventions.

Design

Scoping review guided by Arksey and O'Malley's framework.

Data Sources

We searched CINAHL, MEDLINE, Embase, Emcare, AMED, PsycINFO, Global Health, Social Work Abstracts, JBI EBP, Scopus, Web of Science Core Collection, ProQuest and Informit for studies published between January 2010 and November 2024.

Methods

Two reviewers independently screened studies and extracted data. Analysis followed the Patterns, Advances, Gaps, Evidence for Practice and Research recommendations framework.

Results

Seventeen studies involving 1275 carers were included. Carer experiences were summarised into four themes: (1) cultural and communication barriers; (2) role ambiguity and practical challenges; (3) limited involvement in discharge planning and (4) barriers to accessing support and services. Perceptions of transitional care interventions were mixed. While some interventions improved carer preparedness and reduced stress, most lacked cultural tailoring and did not address carers' psychosocial and communication needs.

Conclusion

Culturally and linguistically diverse informal carers face challenges navigating transitional care. While involving them in care planning improves outcomes, implementation remains inconsistent. Emotional support and culturally tailored services are insufficient.

Implications for the Profession and/or Patient Care

There is a need for culturally and linguistically tailored transitional care programmes that prioritise carer education and communication support. Key areas for improvement include: (1) health literacy and system navigation; (2) involvement in care planning; (3) communication with providers; (4) psychosocial and emotional support and (5) culturally appropriate services. Future research should explore the unique emotional and psychosocial needs of these carers to inform targeted support strategies.

Reporting Method

This review follows the PRISMA guideline for reporting.

Patient or Public Contribution

No patient or public contribution.

Reduced levels of mitochondrial ribosomal protein <i>MRPL54</i> does not alter Apc related adenoma formation

by Claudia N. Spaan, Eileen Daniels, Wouter L. Smit, Ruben J. de Boer, Joana Silva, Jacqueline L. M. Vermeulen, S. Meisner, Vanesa Muncan, Riekelt H. Houtkooper, Jarom Heijmans

Reprogramming of energy metabolism is one of the hallmarks of cancer cells and mutations that modify wild type intestinal cells to colon carcinomas increases cellular energy expenditure. Mitochondria are the main site for ATP production in (cancer) cells and disrupting their function results in impaired tumor forming efficacy. The mitochondrial ribosomal proteins (MRPs) constitute the ribosome specifically in mitochondria, and as such are crucial for the translation process of the electron transport chain complex subunits. We hence aimed to explore the consequence of reduced MRP expression on adenomagensis and investigate this in a genetic mouse model with bodywide heterozygosity for Mrpl54. We show that Mrpl54 heterozygosity does not alter adenoma formation, intestinal proliferation or apoptosis in a heterozygous Apc model. Furthermore, diminished Mrpl54 expression did not decrease stemness or global parameters of metabolism in colorectal cancer cell lines.

Testing the Biomechanical Protection by Sacral Border Dressings in a Laboratory‐Based Model

ABSTRACT

Pressure mitigating dressings are one component of pressure ulcer/injury prevention strategies. There are many such devices on the market, but little data to compare them by. Herein we share our results of comparing sacral border dressings' capacity to mitigate deformations due to lateral forces. A modified version of a published digital image correlation-based technique was used to monitor the distortions of a cast silicone sheet under varying loads. Four sacral border dressings were compared to no dressing with three replicates for each. Empirical displacements within the gel were quantified via image analysis and compared via two-way ANOVA followed by Tukey's HSD test. Full field displacements were interpolated from the empirical data and the full field strains and shear were calculated and plotted. All four dressings were statistically significantly different from the control, but not among each other with magnitudes on the order of a hair's breadth. The maximum strains measured among the dressings were not significantly different in the direction of applied force, but two of the dressings were found to differ in the orthogonal direction, and those same dressings had computed strains equal to the control in the direction of the applied force. Our lab-based data indicate that four commercially available sacral border dressings reduce lateral strain under most conditions and shear under all conditions compared to no dressing. While the absence of clear tissue failure criteria limits direct clinical translation, these findings provide a straightforward and quantitative foundation for pre-clinical evaluation of sacral dressings.

Strategies to Position the Clinical Academic Nurse in University, Teaching and General Hospitals

ABSTRACT

Aim

Explore the perspectives of Clinical Academic Nurses and stakeholders on strategies for positioning Clinical Academic Nurses in Dutch hospitals.

Design

A descriptive qualitative study.

Methods

Semi-structured interviews and focus groups were conducted with Clinical Academic Nurses and stakeholders from five hospitals involved in the positioning of Clinical Academic Nurses. Data was analysed using thematic analysis to identify strategies for positioning these nurses.

Results

Four themes emerged: (1) ‘Supportive vision and culture’ is crucial for a shared vision and enables a culture for consistent support in the positioning, (2) A clear defined and strategic ‘Position of Clinical Academic Nurses’ is needed for uniform positioning, (3) ‘Research infrastructure’ describes the important supportive elements, and (4) ‘Leadership’ describes Clinical Academic Nurses' pioneering role in aligning research with organisational goals which strengthens their position.

Conclusion

Positioning Clinical Academic Nurses in hospitals requires a vision, well-defined positions, a research infrastructure, and leadership support. Long-term strategic investments are needed to integrate research into clinical nursing practice and recognise Clinical Academic Nurses as strategic assets.

Implications for Policy and Practice

Positioning Clinical Academic Nurses requires visionary leadership, institutional commitment and investment in research infrastructure. The Nurse Advisory Board should support this by aligning positioning, support and evaluation with strategic policies. Strategic hospital-academic partnerships foster research, education, mentorship and grant support. Clinical Academic Nurses should set measurable goals, proactively align research with clinical priorities and increase visibility to advance nursing practice.

Impact

This study identifies empirically grounded insights into strategies to position Clinical Academic Nurses and offers actionable insights for management, policymakers and Clinical Academic Nurses to strengthen knowledge infrastructure and improve patient care.

Reporting Method

COREQ.

Patient or Public Contribution

Limited patient and public involvement, focusing on feedback on preliminary results.

Doctoral Education: The Need for Radical Reform

ABSTRACT

In this final editorial of our group of four, we take up the challenge of thinking about radical reform of doctoral education. We contend that without decisive action, nursing risks losing its capacity to shape the future of healthcare. Therefore we suggest there is a need for radical reform of doctoral education, focusing on three key areas.

Can topical coconut oil reduce late-onset sepsis in extremely preterm infants? A pragmatic cluster-randomised controlled trial protocol

Por: Strunk · T. · Mountain · J. · Gordon · A. · Deshpande · G. · van den Boom · J. · DePaoli · A. G. · Jacobs · S. · Giannoutsos · N. · Doherty · D. A. · Patole · S.
Introduction

Infants born before 28 weeks’ gestation account for approximately 75% of neonatal morbidity and mortality. Late-onset sepsis (LOS) affects around 25% of these infants and is associated with an increased risk of adverse long-term outcomes. The topical application of coconut oil has been used for centuries in newborn care. Coconut oil is rich in saturated fatty acids, several of which have demonstrated antimicrobial properties. It is considered safe for extremely preterm infants, improves skin condition and may reduce the incidence of LOS.

Methods and analysis

This is a pragmatic, cluster-randomised, two-arm, parallel-group, multicentre, phase III clinical trial evaluating the effect of topical coconut oil versus routine skin care on the incidence of LOS in extremely preterm infants. Participating neonatal units will be cluster-randomised, and all infants born at

Ethics and dissemination

Following ethical approval, patients will be recruited at participating sites under a waiver of consent with opt-out framework. The trial results will be disseminated through conferences, media sources and publication in relevant peer-reviewed journals.

Trial registration number

ACTRN12620001332910.

Assessment of health-related quality of life, cognitive, physical and psychological impairments in critically ill adults after status epilepticus (POSEIDON 2): protocol for a multicentre longitudinal study

Por: Legriel · S. · Bernard · C. · Sboui · G. · Sigaud · F. · Lascarrou · J.-B. · Mayenco-Cardenal · N. · Chelly · J. · Bruel · C. · Mongardon · N. · Marzouk · M. · Quenot · J.-P. · Hugues · R. · Schnell · D. · Beuret · P. · Bailly · P. · Lesieur · O. · Argaud · L. · Chambon · R. · Jacq · G.
Introduction

Status epilepticus (SE) in adults is a serious neurological emergency that can lead to high morbidity and mortality rates. Although functional outcomes are often assessed using general scoring systems, limited data on health-related quality of life (HRQoL) in patients admitted to intensive care units (ICUs) are still limited. Furthermore, comprehensive evaluations of patient-reported physical, cognitive, mental health and psychological outcomes are lacking in this population. POSEIDON 2 aims to assess HRQoL and cognitive, physical and psychological impairments at 3 and 12 months after ICU discharge following SE and quantify caregiver burden.

Methods and analysis

POSEIDON 2 is a prospective, multicentre, longitudinal study conducted in 19 French ICUs. The study combines data from the SE ICTAL Registry with data from patients who survived admission to the ICU for SE, who will be recruited for the study. The study also includes patient-reported outcome (PRO) data collected 3 (M3) and 12 (M12) months after discharge from the ICU using validated instruments. The Zarit scale will be used to measure the burden on caregivers at M3 and M12. The primary endpoint is the prevalence of overall HRQOL impairment at M3 and M12, as defined by dichotomous scores on the physical and mental components of the 36-Item Short Form Health Survey compared with those of the general population. Secondary endpoints include domain-specific impairments, such as cognitive function, dependence, mental health and patient experiences. The sample size has been calculated based on an estimated prevalence of 75% for HRQoL impairment, with a planned sample size of 140 patients.

Ethics and dissemination

The POSEIDON 2 study protocol received ethical approval from the ethics committee ‘Comité de Protection des Personnes Ouest VI’ on 5 October 2023 (#2023-A01223-42). The study is conducted in accordance with the Declaration of Helsinki, Good Clinical Practice and the regulatory requirements of France. Written informed consent is obtained from participants, who are able to decline participation or withdraw from the study at any time. Findings will be disseminated through publication in peer-reviewed journals and presentations at scientific conferences.

Trial registration number

NCT06100978.

Doctoral Education in Nursing Is a ‘Special Issue’

ABSTRACT

The extent to which the analysis of the state of play of doctoral education and suggested ways forward are seen as being radical is of course dependent on the context within which nursing research programs currently exist. We are aware that no one size fits all contexts, but we are also aware of a critical need to challenge dominant perspectives and practices and work toward a radical repositioning of the nursing PhD. At a time when the narrative of nursing shortages is pervasive, we need to be positioning nursing research and researchers at the heart of the solution. Without a radical reconsideration of how we build sustainable research teams, the opportunity will bypass us. The special issue on doctoral education deliberately set out to be disruptive, to surface critical questions and trigger a conversation that needs to be had. We are open to continuing this conversation.

Head Nurse's Ethical Leadership, Work Environment and Patients' Outcomes: A Multicentre Cross‐Sectional Multilevel Study

ABSTRACT

Aim

To investigate the relationship between nursing ethical leadership style, work environment (workload, interpersonal conflicts) and patients' objective nursing-sensitive outcomes (accidental falls, pressure ulcers, nosocomial infections, restraints and deaths).

Design

Nationwide multicentre cross-sectional multilevel survey.

Methods

Validated self-report scales were used to assess nurses' perceptions of ethical leadership, workload and interpersonal conflict. Nursing staffing and objective patient' nursing-sensitive outcomes were measured at the ward level. Descriptive and inferential analyses were conducted. Structural equation modelling examined the relationships among these variables based on Donabedian's conceptual framework.

Results

Data from 2349 nurses across 158 wards in 25 Italian acute care hospitals were analysed. The multilevel model showed an excellent fit. Ethical leadership was negatively associated with both workload and interpersonal conflict. Workload was significantly linked to higher rates of pressure ulcers, falls and deaths in patients. Ethical leadership was indirectly associated with improved patient outcomes through reduced workload.

Conclusion

Head nurses' ethical leadership has a pivotal role in shaping the work environment and enhancing nursing-sensitive outcomes by reducing workload and fostering positive interpersonal dynamics. These findings emphasise the need for healthcare organisations to invest in ethical leadership development as a critical strategy for improving care quality and promoting better patient outcomes.

Impact

These findings emphasise the need for healthcare organisations to invest in ethical leadership development as a critical strategy for improving care quality and promoting safer, more effective patient outcomes.

Reporting Method

The study adhered to The Strengthening the Reporting of Observational Studies in Epidemiology checklist.

No Patient or Public Contribution

This study did not include patient or public involvement.

What Does This Paper Contribute to the Wider Global Clinical Community?

Cultivating moral values and principles in leadership enables leaders to effectively communicate these values to their staff. Addressing unethical behaviours, fostering open dialogue about organisational ethics, and supporting leaders in the ethical decision-making process contribute to a healthier nurses' work environment. Healthcare organisations investing in the development and promotion of ethical leaders improve care quality.

Protocol Registration

The study was registered in the research registry (www.researchregistry.com) under the record number (researchregistry7418), following a published protocol.

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