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N-terminal proBNP adds prognostic value to high-sensitivity cardiac troponin I in elective thoracic surgery: an observational cohort study

Por: Alonso · M. · Popova · E. · De Miguel · M. · Garcia-Osuna · A. · Gonzalez-Tallada · A. · Ordonez-Llanos · J. · Jauregui · A. · Trujillo · J. C. · Martin Grande · A. · Martinez-Tellez · E. · Parera · A. · Planas · G. · Trujillo · L. · Butron · D. · Sola-Roca · J. · De Nadal · M.
Background

Perioperative myocardial injury (PMI) is a common complication following non-cardiac, particularly thoracic, surgery and is associated with increased cardiovascular risk. Although guidelines recommend cardiac biomarker monitoring to detect PMI, its implementation in routine clinical practice remains limited.

Objective

To evaluate the combined use of high-sensitivity cardiac troponin I (hs-cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in predicting major adverse cardiovascular events (MACE) following elective thoracic surgery, and to determine whether NT-proBNP provides incremental prognostic value beyond hs-cTnI alone.

Design

Multicentre observational cohort study.

Setting

Conducted between February 2021 and November 2023 in three Spanish tertiary hospitals.

Participants

Patients aged ≥45 years scheduled for elective thoracic surgery involving lung resection (pneumonectomy, lobectomy, bilobectomy or segmentectomy) under general anaesthesia. Exclusion criteria included urgent or non-thoracic surgery, active infection or sepsis and a history of severe heart failure (ejection fraction

Main outcome measures

Combined measurement of hs-cTnI and NT-proBNP at baseline (preoperatively) and at 24 and 48 hours postoperatively.

PMI was defined as hs-cTnI ≥45 ng/L at 24 and/or 48 hours or a ≥20% increase from baseline in patients with elevated preoperative concentrations.

Results

Among 475 patients, PMI occurred in 11.8%. PMI had higher rates of prior stroke (12.5% vs 2.9%; p=0.004), smoking history (85.7% vs 64.0%; p=0.001) and severe renal dysfunction (7.1% vs 0.7%; p=0.001), with similar Revised Cardiac Risk Index distribution. Patients with PMI also had greater postoperative elevations of hs-cTnI and NT-proBNP (p

Conclusions

Combined hs-cTnI and NT-proBNP assessment improves perioperative cardiovascular risk stratification beyond ischaemia.

Trial registration number

NCT04749212

Implementation of a digital tool for monitoring and managing the emotional and cognitive sequelae of post-intensive care syndrome: ICURA study protocol for a randomised clinical trial

Por: Llabres-Alvarez · E. · Riera-Sagrera · M. · Llompart-Casasnovas · A. · Salva · P. · Castro · A. · Godoy-Gonzalez · M. · Dona-Lopez · E. · Lopez-Aguilar · J. · Jodar · M. · Navarra-Ventura · G. · Gili · M. · Roca · M. · Fernandez-Gonzalo · S.
Introduction

Intensive care units (ICUs) can be a particularly challenging environment for patients who are mentally vulnerable. In addition to the physical stress associated with critical illness and its management, there are physiological and psychosocial factors that can negatively impact a patient’s mental health. Approximately half of ICU survivors will experience post-intensive care syndrome, a set of emotional, neuropsychological and physical sequelae that can significantly affect patients’ functionality and quality of life, both in the short and long term. The main objective of this study is to investigate whether the ICU Recovery Answers (ICURA) digital follow-up platform can effectively detect emotional and cognitive problems in critically ill patients and its impact on functionality and health-related quality of life during the first year after ICU discharge.

Methods and analysis

Multicentre longitudinal prospective study involving ICU adult patients, with randomised follow-up comparing a telemedicine monitoring programme versus usual medical care during 1 year after discharge. A total of 360 participants will be recruited during their ICU admission in two hospitals in Spain. Efficacy outcomes will focus on participants’ level of functioning, assessed with the WHO Short Disability Assessment Schedule, and quality of life, measured with the 12-Item Short Form Survey at 1, 6 and 12 months after ICU discharge. Emotional state and cognitive impairment will be evaluated using the Patient Health Questionnaire-9, Generalised Anxiety Disorder-7 and Treatment-Outcome Post-Traumatic Stress Disorder Scale and the Montreal Cognitive Assessment by telephone at 1, 3, 6, 9 and 12 months after ICU discharge.

Ethics and dissemination

The implementation of this project is expected to have a direct impact on the satisfaction of ICU survivors, improving their well-being, personalised follow-up and quality of life. Results from this study will be disseminated at various scientific conferences, national and international meetings, and will be shared with the general public and other relevant parties. The dissemination of these results will occur through scientific publications, allowing the medical and scientific community to benefit from the study’s findings. Ethics approval from the Ethics Board of Parc Taulí Foundation and Balearic Islands with reference numbers 2022/3031 and IB 5072/22 PI: Protocol version 1 of 18 November 2022.

Trial registration number

NCT06504979.

Individual and Institutional Factors Associated With Urinary Incontinence Among Nursing Home Residents: A Multilevel Analysis

ABSTRACT

Aims

(1) To analyse individual and institutional-level factors associated with urinary incontinence in older adults living in nursing homes; (2) to estimate the prevalence of urinary, faecal and double incontinence in nursing home residents.

Design

Cross-sectional study.

Methods

Residents aged 65+ living in 22 nursing homes in Catalonia (Spain) were included. Descriptive, bivariate, and multilevel analyses were performed.

Results

The final sample comprised 452 residents (75.9% female, mean age of 87.0 years). The prevalence of urinary, faecal and double incontinence was 77.5%, 46.1% and 45.7%, respectively. Urinary incontinence was statistically significantly associated with neurological conditions, moderate cognitive impairment, moderate dementia, severe cognitive impairment, very severe cognitive impairment and age.

Conclusion

Approximately three out of four nursing home residents suffered from urinary incontinence and almost half of the sample from faecal or double incontinence. Individual-level factors (cognition, neurological conditions and age) played a more important role than institutional-level factors for urinary incontinence.

Implications for the Profession and Patient Care

The findings of this study highlight the importance of individual-level interventions to prevent and manage urinary incontinence in nursing homes.

Impact

In Catalonian nursing homes, individual factors such as cognitive impairment and neurological conditions were more strongly associated with urinary incontinence than institutional factors. This has implications for improving care provided to older adults, particularly those with dementia and neurological conditions.

Reporting Method

STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines.

Patient or Public Contribution

Nursing home residents were not involved in this study.

Recuperación de la actividad física y deportiva cuando eres portadora de una ostomía

Objetivo principal: Identificar las intervenciones adecuadas, desde el preoperatorio, para recuperar progresivamente la actividad previa a la formación del estoma, de forma segura. Metodología: Búsqueda de evidencias, siguiendo el modelo PRAXIS. Recomendaciones de Buena Práctica: a) motivar el autocuidado en el preoperatorio, b) instruir, el personal de hospitalización, en la movilización  temprana adecuada c) promover la actividad física progresiva de forma individual d) instruir en habilidades y estrategias para una práctica deportiva segura Prácticas de autocuidado: saber manejarse y adaptarse a los cambios físicos, conocer tu cuerpo y desmitificar miedos,  disfrutar de la actividad deportiva en grupo,  compartir experiencias con otras personas ostomizadas.

Manejo de las técnicas de depuración extracorpórea en el paciente Covid-19

Objetivo principal: describir la experiencia adquirida durante los tres primeros meses de pandemia en nuestra unidad de cuidados intensivos durante el manejo del paciente COVID-19, y conocer las características de estos pacientes y de los tratamientos de Técnicas Continuas de Depuración Extracorpórea (TCDE) aplicados. Método: Estudio descriptivo observacional retrospectivo de pacientes Covid-19 que precisaron TCDE. Resultado principal: El aumento considerable de las cargas de trabajo junto al elevado número de pacientes que precisaron de TCDE, se combatió con la reorganización continua del trabajo de enfermería y con el desarrollo de estrategias para evitar el riesgo de contagio. En los pacientes con COVID-19 a los que se aplicó TCDE, la mortalidad alcanzó el 53,33%, y el 20% pacientes pudieron ser dados de alta dentro del período de observación. Conclusión principal: La formación en TCDE ofrecerá a todos los pacien-tes una oportunidad de una favorable evolución. Esta pandemia está demostrando la necesidad de la especialización de las enfermeras, dotándolas de conocimientos teóricos y prácticos.

Evaluación del manejo del inhalador presurizado de dosis media en el paciente pediátrico

Objetivo principal: Evaluar el manejo del inhalador presurizado de dosis media en el paciente pediátrico. Metodología: Estudio exploratorio transversal y evaluativo a través de un cuestionario con preguntas cerradas. Se creó un índice (Ic; escala de 0 a 1) para valorar el uso correcto de los inhaladores. Resultados principales: La puntuación media obtenida del uso correcto fue de Ic=0,64 (d.e. +/- 0,176). Aun-que este índice es superior en los casos en los que se declara haber recibido una explicación (Ic=0,65) con relación a los que indican que no (Ic=0,53), no se encontró significación estadística entre dicha diferencia (p=0,331). Asimismo, se apreció que cuando es el personal de enfermería es quién realiza la explicación el índice es mayor comparado con otros profesionales (Ic=0,7; p=0,23). Conclusión principal: No se encontró ningún niño que no cometiera al menos un error. Observamos un índice de uso correcto más elevado cuando la explicación parte de enfermería.

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