Association of leuko-glycemic index with mortality in ICU patients with Acute kidney injury: A retrospective multicenter cohort study

by Xuejin Ye, Sheng Chen, Lin Guo, Xiaohan Ma, Lingling Wu, Yiwen Li, Ting Zhang, Peng Jiang, Hongjun Gao

Acute kidney injury (AKI) complicates the course of critical illness and carries high short- and long-term mortality rates; however, reliable early prognostic markers remain limited. The leuko-glycemic index (LGI), the product of white blood cell counts and blood glucose, has shown prognostic value in other acute conditions; however, its role in intensive care unit (ICU) patients with AKI remains unexplored.

In this multicenter retrospective cohort study, we analyzed 112,235 adult ICU admissions from the MIMIC-IV (n = 54,840) and eICU-CRD (n = 57,395) databases. Patients with multiple ICU stays and those aged Results

Higher LGI quartiles were associated with progressively worse survival (p  Conclusion

LGI may be an independent biomarker associated with short-term mortality in ICU patients with AKI. Its potential clinical relevance warrants further investigation and validation in larger cohorts.