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The number of risk prediction models for sarcopenia in patients undergoing maintenance haemodialysis (MHD) is increasing. However, the quality, applicability, and reporting adherence of these models in clinical practice and future research remain unknown.
To systematically review published studies on risk prediction models for sarcopenia in patients undergoing MHD.
Systematic review and meta-analysis of observational studies.
This systematic review adhered to the PRISMA guidelines. Search relevant domestic and international databases, which were searched from the inception of the databases until November 2023. The Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS) checklist was used to extract data. The Prediction Model Risk of Bias Assessment Tool (PROBAST) checklist was used to assess the risk of bias and applicability. The Transparent Reporting of a Multivariate Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) was used to assess the reporting adherence.
A total of 478 articles were retrieved, and 12 prediction models from 11 articles were included after the screening process. The incidence of sarcopenia in patients undergoing MHD was 16.38%–37.29%. The reported area under the curve (AUC) ranged from 0.73 to 0.955. All studies had a high risk of bias, mainly because of inappropriate data sources and poor reporting in the field of analysis. The combined AUC value of the six validation models was 0.91 (95% confidence interval: 0.87–0.94), indicating that the model had a high discrimination.
Although the included studies reported to some extent the discrimination of predictive models for sarcopenia in patients undergoing MHD, all studies were assessed to have a high risk of bias according to the PROBAST checklist, following the reporting guidelines outlined in the TRIPOD statement, and adherence was incomplete in all studies.
CRD42023476067.
To evaluate the relationship between social isolation, loneliness and psychological well-being in patients with inflammatory bowel disease (IBD). Additionally, we examined the mediating effect of disease activity on the relationships between social isolation, loneliness and psychological well-being.
Cross-sectional descriptive study.
A total of 218 participants were recruited from outpatient clinic at a university hospital in Turkey and from the community membership of the patient support group. Participants provided their socio-demographic and disease-related information and completed (online and paper based) the Turkish Lubben Social Network Scale-6, the Turkish UCLA Loneliness Scale Short Form and the Turkish Psychological Well-being Scale. The data were analysed using univariate linear regression analysis. This study adhered to the STROBE checklist for reporting.
The majority of the participants (72%) were socially isolated, and over half (54.1%) reported moderate to high levels of loneliness. Participants also had low psychological well-being. Linear regression analysis revealed that high loneliness level and social isolation were negative predictors of psychological well-being. The results revealed that the effect of social isolation and loneliness on psychological well-being was mediated by disease activity.
In line with the findings, it can be recommended to enhance social support and networks, along with regular psychological evaluation, should be integrated into the holistic care approach for IBD patients.
The findings of this study hold significant implications for the management and support of patients with IBD, particularly within clinical settings in Turkey.
Patients were invited to complete questionnaires. The investigators explained the study's content and purpose, and addressed any concerns during the data collection process.
FreshRSS 