Remimazolam for anesthesia and sedation in pediatric ambulatory surgery: A scoping review protocol

by Yi Zhang, Linyun Wang, Shuang Guo, Qingjun Zeng, Haishan Cui, Yunbo Mo

Remimazolam, an innovative benzodiazepine, exhibits potential for use in anesthesia and sedation for pediatric outpatient procedures, due to its rapid onset, predictable metabolism, and favorable safety profile. While adult studies are increasing, comprehensive evidence for pediatric use remains limited. This scoping review aims to systematically summarize and delineate the existing evidence concerning the application and features of remimazolam in anesthesia and sedation for outpatient pediatric surgical procedures.

To systematically map existing evidence on remimazolam use in pediatric ambulatory surgery anesthesia and sedation, identifying key concepts, evidence sources, and knowledge gaps.

Following JBI methodology and PRISMA-ScR guidelines, we will search multiple databases, as well as the recommendations provided in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension tailored for Scoping Reviews (PRISMA-ScR) statement. A comprehensive search will be performed using multiple databases, which include PubMed/MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, CINAHL, Scopus, Google Scholar, along with Chinese databases like the China National Knowledge Infrastructure (CNKI), WanFang Data, and VIP Information.. All published studies on remimazolam use in patients ≤18 years for ambulatory surgery will be included. Two reviewers will independently screen and extract data using a standardized form.

A meta‐analysis of clinical studies of moxibustion for pressure ulcer healing

Abstract

In this study, we aimed to evaluate the effect of moxibustion on pressure ulcers. A thorough search was performed for articles published from database inception up to 14 December 2023. Randomized controlled trials, which evaluated the effects of moxibustion were included. Finally, 11 relevant trails that enrolled a total of 795 participants met inclusion criteria. The results of meta-analysis suggested beneficial effects of moxibustion for pressure ulcer compared with control on the response rate (RR: 1.21; 95% CI: 1.13–1.29; p = 0.82; I ² = 0%), healing time (MD: −5.69; 95% CI: −9.58 to −1.80; p<0.05; I ² = 97%) and pressure ulcer scale for healing scores (MD: −1.13; 95% CI: −1.36 to −0.89; p = 0.79; I ² = 0%). The evidence suggests that moxibustion possesses satisfactory efficacy in promoting healing of pressure ulcers. However, due to the small number of trials included in this study, as well as the small sample size and high risk of bias, we were unable to draw firm conclusions about the effectiveness of moxibustion for pressure ulcers.

Vitamin D and wound healing: Assessing skin barrier function and implications for chloasma treatment

Abstract

Chloasma, which is distinguished by irregularities in the pigmentation of skin, poses substantial challenge in the field of dermatology. The regulatory influence of vitamin D on the functions of skin cells implies that it may have the capacity to effectively treat chloasma and promote wound healing. To assess the efficacy of vitamin D in chloasma treatment and its impact on the function of skin barrier during the process of wound healing. The research spanned from April 2022 to September 2023, in Shanghai, China, examined 480 individuals who had been diagnosed with chloasma. A double-blind, placebo-controlled clinical trial was utilized to evaluate effectiveness of topical vitamin D3 in treatment of chloasma. Concurrently, randomized control trial investigated the effects of ingested vitamin D3 supplements on the process of wound healing. Transepidermal water loss (TEWL), chloasma severity score changes, wound size reduction and skin hydration levels were critical performance indicators. Statistically, the severity scores of chloasma decreased significantly in the vitamin D treatment group at 3 and 6 months compared with the placebo (p < 0.05). The Vitamin D group exhibited superior wound healing outcomes, including more substantial reduction in lesion size and enhanced skin barrier function, as evidenced by increased skin hydration and decreased TEWL (p < 0.05). Vitamin D substantially mitigated the severity of chloasma and has beneficial effect on wound healing and integrity of the skin barrier. Based on the results obtained, vitamin D exhibited promise as a therapeutic intervention in the field of dermatology, specifically in treatment of chloasma and promotion of wound recovery.