Conectar
The lack of systematic and comprehensive clinical nutrition management practices for patients with chronic wounds necessitates the construction of a scientifically-based, standardised, normalised nutrition management guidance procedure for these patients in clinical settings. The purpose of this study was to: (i) summarise the best evidence for nutrition management in patients with chronic wounds by performing a systematic literature search and rigorous evaluation, and (ii) construct a nutrition management guidance flowchart for these patients based on best evidence. We reported the best evidence summary for nutrition management in patients with chronic wounds by following the Evidence Summary Reporting Standard of Fudan University Evidence-Based Care Center. An expert panel was established to construct a flowchart of nutrition management guidance for patients with chronic wounds by discussing existing evidence entries. After the quality evaluation, 17 studies (5 guidelines and 12 systematic reviews) were included, which provided extractable data for this summary of evidence. The best evidence of nutrition management in patients with chronic wounds was summarised, and a nutrition management guidance flowchart based on this was constructed, which can provide references for medical staff to guide nutrition management for patients with chronic wounds. Looking ahead, more high-quality research is needed to focus on specific personalised nutrition management programmes for patients with chronic wounds.
Macrophages play a crucial role in aiding all phases of the wound-healing process and has garnered increasing attention recently. Although a substantial body of related studies has been published, there remains a lack of comprehensive bibliometric analysis. In this study, we collected 4296 papers from the Web of Science Core Collection database. Three tools including CiteSpace, VOSviewer and one online analytical platform were employed to conduct bibliometric analysis and data visualization. Our results revealed that the annual number of publications related to macrophage and wound healing has increased exponentially with the year. The United States and China stand as the primary driving forces within this field, collectively constituting 58.2% of the total publication output. The application of biomaterials was one of the most concerned research areas in this field. According to references analysis, the current research focus has shifted to diabetic wound healing and regulating macrophage polarization. Based on the keywords analysis, we identified the following research frontiers in the future: exosomes and other extracellular vesicles; bio-derived materials and drug delivery methods such as nanoparticles, scaffolds and hydrogels; immunomodulation and macrophage polarization in the M2-state; chronic wounds, particularly those associated with diabetes; antimicrobial peptides; and antioxidant. Additionally, TNF, IL-6, IL-10, TGF-β1 and VEGF ranked as the five genes that have garnered the most research attention in the intersection of macrophage and wound healing. All in all, our findings offered researchers a holistic view of the ongoing progress in the field of macrophages and wound healing, serving as a valuable reference for scholars and policymakers in this domain.
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